Zhanjun Dou

Area of research

Physiology · Endocrine and Autonomic Systems

Research interest

Research topics from publications: CB1 receptor antagonist rimonabant protects against chronic intermittent hypoxia-induced renal injury in rats; Bone Metabolic Markers in Patients with Obstructive Sleep Apnea Syndrome; CB1 receptor antagonist rimonabant protects against chronic intermittent hypoxia-induced bone metabolism disorder and destruction in rats; Analysis of the characteristics of intestinal microbiota in patients with different severity of obstructive sleep apnea; Role of the endogenous cannabinoid receptor 1 in brain injury induced by chronic intermittent hypoxia in rats; Regulation of the CB1R/AMPK/PGC-1α signaling pathway in mitochondria of mouse hearts and cardiomyocytes with chronic intermittent hypoxia; Inhibiting the CB1 receptor in CIH-induced animal model alleviates colon injury; [Preliminary analysis of intestinal microflora in patients with different severity of OSAHS]. Representative work: BACKGROUND: Obstructive sleep apnoea (OSA) induced chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH). Our study investigate the mechanism underlying CIH-induced renal damage and whether the cannabinoid receptor 1 (CB1R) antagonist rimonabant (Ri) alleviates CIH-induced renal injury. METHODS: Male Sprague-Dawley rats were randomly divided into five groups: one normal control (NC) group, two chronic intermittent hypoxia (CIH) groups, and two CIH + Ri groups. Rats in the NC groups were exposed to room air, while the CIH groups were exposed to a CIH environment for 4 weeks (4w CIH group) and 6 weeks (6w CIH group), respectively. Additionally, rats in the CIH + Ri grou Background: Obstructive sleep apnea syndrome (OSAS) is prevalent in obesity and is associated with many metabolic abnormalities. The relationship between OSAS and bone metabolism is still unclear. The aim of this study was to investigate the relationship between the severity of OSAS and bone metabolic markers. Methods: A total of 119 obese males were enrolled in this study in spring months from 2015 to 2017. All candidates underwent polysomnography, and their bone mineral density (BMD) and the serum levels of total procollagen type 1 N-terminal propeptide (t-P1NP), N-terminal midfragment of osteocalcin (N-MID), β-C-terminal telopeptide of type 1 collagen (β-CTX), vitamin D (VD), and parathyr

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