Area of research
Neurology · Epidemiology
Research interest
Research focused on Parkin and Mitophagy, with related work in PINK1, Monoamine oxidase, Monoamine oxidase B. Notable publications include 'Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin', 'A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson’s disease models', and 'Potassium channel dysfunction in human neuronal models of Angelman syndrome'.
Ergothioneine Treatment Ameliorates the Pathological Phenotypes of Parkinson's Disease Models
In situ dual-activated NIRF/PA carrier-free nanoprobe for diagnosis and treatment of Parkinson's disease
Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation
Role of Exosomes in the Pathogenesis and Theranostic of Alzheimer’s Disease and Parkinson’s Disease
Vitamin B12 Ameliorates the Pathological Phenotypes of Multiple Parkinson’s Disease Models by Alleviating Oxidative Stress
From 2D to 3D: Development of Monolayer Dopaminergic Neuronal and Midbrain Organoid Cultures for Parkinson’s Disease Modeling and Regenerative Therapy
Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice
Linking Heat Shock Protein 70 and Parkin in Parkinson’s Disease
Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application
BACE2: A Promising Neuroprotective Candidate for Alzheimer’s Disease
Lewy Body–like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α‐Synuclein Mutations
Activation of Autophagy Ameliorates Age-Related Neurogenesis Decline and Neurodysfunction in Adult Mice
A Flexi‐PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy
Potassium channel dysfunction in human neuronal models of Angelman syndrome
Visualization of Intra‐neuronal Motor Protein Transport through Upconversion Microscopy
PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy
The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson’s Disease
Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin
Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria
Parkin Regulation and Neurodegenerative Disorders
Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1
Nutraceuticals in Parkinson’s Disease
A Small‐Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease
Mitochondrial dysfunction and Parkinson disease: a Parkin–AMPK alliance in neuroprotection
A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson’s disease models
Endocytic Pathways Downregulate the L1-type Cell Adhesion Molecule Neuroglian to Promote Dendrite Pruning in Drosophila
DAMPs and neurodegeneration
Molecular Events Underlying Parkinson’s Disease – An Interwoven Tapestry
AMP Kinase Activation Mitigates Dopaminergic Dysfunction and Mitochondrial Abnormalities in<i>Drosophila</i>Models of Parkinson's Disease
Parkin Pathway Activation Mitigates Glioma Cell Proliferation and Predicts Patient Survival