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Frank L. Heppner

German Cancer Society · DE
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Area of research
Neurology · Genetics
Research interest
Research interests include Neuroinflammation and Neurodegeneration Mechanisms, Glioma Diagnosis and Treatment, Alzheimer's disease research and treatments, and Prion Diseases and Protein Misfolding.
h-index
83
citations
36,553
works
485
NIH funding
primary concept
Medicine
email

Recent publications

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
Cell 2025cited by 26position: middledoi
Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis
Nature Aging 2025cited by 21position: lastdoi
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
Cancer Cell 2025cited by 14position: middledoi
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
medRxiv 2025cited by 5position: middledoi
Analysis of the spatiotemporal dynamics of vascular injury and regeneration following experimental Spinal Cord Injury
Brain and Spine 2025cited by 5position: middledoi
Analysis of Neuronal Excitability Profiles for Motor-Eloquent Brain Tumor Entities Using nTMS in 800 Patients
Cancers 2025cited by 2position: middledoi
Outcome-associated factors in a molecularly defined cohort of central neurocytoma
Acta Neuropathologica 2025cited by 1position: middledoi
AI-based histopathological classification of central nervous system tumours
Research Square 2025cited by 1position: middledoi
Neurofilament light chain as a marker of peripheral nerve damage in vasculitic neuropathy? A cross‐compartmental correlation analysis in patients undergoing nerve biopsy
Brain Pathology 2025cited by 1position: middledoi
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19
Nature Neuroscience 2024cited by 65position: middledoi
Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease
Cell Reports Medicine 2024cited by 39position: middledoi
Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia
Journal of Neuroinflammation 2024cited by 27position: middledoi
Alzheimer's Disease Risk Gene <i>SORL1</i> Promotes Receptiveness of Human Microglia to Pro‐Inflammatory Stimuli
Glia 2024cited by 12position: middledoi
Testicular large B‐cell lymphoma is genetically similar to PCNSL and distinct from nodal DLBCL
HemaSphere 2024cited by 8position: middledoi
Identification of a Therapeutic Window for Neurovascular Unit Repair after Experimental Spinal Cord Injury
Journal of Neurotrauma 2024cited by 5position: middledoi
TTF-1 negativity in synchronous M1b/M1c wildtype lung adenocarcinoma brain metastases predicts worse survival with increased risk of intracranial progression
Journal of Neuro-Oncology 2024cited by 4position: middledoi
A facility for laboratory mice with a natural microbiome at Charité – Universitätsmedizin Berlin
Lab Animal 2024cited by 2position: middledoi
Meeting report of the 20th International Congress of Neuropathology (<scp>ICN</scp>) 2023 in Berlin
Brain Pathology 2024cited by 1position: middledoi
Prognostic Value of Thyroid Transcription Factor 1 Expression in Newly Diagnosed, Treatment-Naïve Non-Small-Cell Lung Cancer Adenocarcinoma Brain Metastasis
Brain and Spine 2024cited by 0position: middledoi
The neurobiology of SARS-CoV-2 infection
Nature reviews. Neuroscience 2023cited by 63position: lastdoi
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19
Nature Communications 2023cited by 59position: middledoi
IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice
Nature Neuroscience 2023cited by 45position: middledoi
The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation
Journal of Neuroinflammation 2023cited by 38position: middledoi
Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles
Acta Neuropathologica Communications 2023cited by 35position: middledoi
Development of Beta-Amyloid-Specific CAR-Tregs for the Treatment of Alzheimer’s Disease
Cells 2023cited by 30position: middledoi
A Novel Type of IDH-wildtype Glioma Characterized by Gliomatosis Cerebri-like Growth Pattern, TERT Promoter Mutation, and Distinct Epigenetic Profile
The American Journal of Surgical Pathology 2023cited by 24position: middledoi
Radiation Therapy in Alzheimer's Disease: A Systematic Review
International Journal of Radiation Oncology*Biology*Physics 2023cited by 11position: middledoi
Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and development
Communications Biology 2023cited by 7position: lastdoi
A prospective observational study of real-world treatment and outcome in secondary CNS lymphoma
European Journal of Cancer 2023cited by 6position: middledoi
ApoE Alzheimer’s Disease Aβ-amyloid plaque morphology varies according to APOE isotype
Research Square 2023cited by 4position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Peter Vajkoczy · Humboldt-Universität zu Berlin12 papers (2017–2025)Julia Onken · German Society of Surgery11 papers (2017–2024)Helena Radbruch · Berlin Institute of Health at Charité - Universitätsmedizin Berlin10 papers (2021–2024)David Capper · German Cancer Research Center8 papers (2021–2025)Werner Stenzel · Humboldt-Universität zu Berlin8 papers (2012–2025)Josefine Radke · Deutschen Konsortium für Translationale Krebsforschung7 papers (2017–2022)Arend Koch · Heidelberg University6 papers (2012–2024)David Kaul · University of Potsdam5 papers (2012–2024)Jenny Meinhardt · Charité - Universitätsmedizin Berlin5 papers (2021–2025)Elisa Schumann · Humboldt-Universität zu Berlin5 papers (2019–2022)David Horst · German Cancer Research Center5 papers (2021–2024)Marina Jendrach · Humboldt-Universität zu Berlin4 papers (2018–2023)Simon Streit · Humboldt-Universität zu Berlin4 papers (2021–2025)Kiara Freitag · Humboldt-Universität zu Berlin4 papers (2019–2023)Burkhard Becher · University of Zurich4 papers (2012–2023)Sefer Elezkurtaj · Federal Ministry of Health4 papers (2021–2021)Stefan Prokop · Allen Institute for Brain Science3 papers (2012–2023)Christoph Harms · University of Hong Kong3 papers (2021–2024)Hans-Hilmar Goebel · University of Applied Sciences Mainz3 papers (2012–2021)Randi Koll · Humboldt-Universität zu Berlin3 papers (2019–2022)
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