Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Receptor Mechanisms and Signaling, Neuropeptides and Animal Physiology, Mass Spectrometry Techniques and Applications, and Protein Kinase Regulation and GTPase Signaling.
A positive allosteric modulator of the β1AR with antagonist activity for catecholaminergic polymorphic ventricular tachycardia
Role of the V2R–βarrestin–Gβγ complex in promoting G protein translocation to endosomes
Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin
Allosteric modulator potentiates β2AR agonist–promoted bronchoprotection in asthma models
GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision
β-Arrestin–Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection
Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor
The GPCR–β-arrestin complex allosterically activates C-Raf by binding its amino terminus
Mechanism of β <sub>2</sub> AR regulation by an intracellular positive allosteric modulator
Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility
GPCR signaling: conformational activation of arrestins
Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure
Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor
Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1–Regulated Lactate Metabolism
Visualization of arrestin recruitment by a G-protein-coupled receptor
Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor