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David J. Hackam

Johns Hopkins University · US
Area of research
Nutrition and Dietetics · Pulmonary and Respiratory Medicine
Research interest
Research interests include Infant Nutrition and Health, Neonatal Respiratory Health Research, Clinical Nutrition and Gastroenterology, and Immune Response and Inflammation.
h-index
78
citations
17,006
works
339
NIH funding
primary concept
email

Recent publications

Bench to bedside — new insights into the pathogenesis of necrotizing enterocolitis
Nature Reviews Gastroenterology & Hepatology 2022cited by 180position: firstdoi
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity
Science Advances 2021cited by 68position: middledoi
The human milk oligosaccharides 2’-fucosyllactose and 6’-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling
Pediatric Research 2020cited by 189position: lastdoi
Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
Cell Reports 2019cited by 47position: middledoi
Toll-Like Receptor–Mediated Intestinal Inflammatory Imbalance in the Pathogenesis of Necrotizing Enterocolitis
Cellular and Molecular Gastroenterology and Hepatology 2018cited by 179position: firstdoi
Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain
Science Translational Medicine 2018cited by 150position: lastdoi
A Roadmap for Aspiring Surgeon-Scientists in Today's Healthcare Environment
Annals of Surgery 2018cited by 108position: lastdoi
Scholarly Research Projects Benefit Medical Students’ Research Productivity and Residency Choice: Outcomes From the University of Pittsburgh School of Medicine
Academic Medicine 2018cited by 46position: middledoi
Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg<sup>9</sup>bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration
American Journal of Physiology-Lung Cellular and Molecular Physiology 2017cited by 352position: middledoi
Pediatric choledochal cysts: diagnosis and current management
Pediatric Surgery International 2017cited by 166position: middledoi
Necrotizing enterocolitis: Pathophysiology from a historical context
Seminars in Pediatric Surgery 2017cited by 142position: firstdoi
The neonatal window of opportunity—early priming for life
Journal of Allergy and Clinical Immunology 2017cited by 128position: middledoi
Necrotizing enterocolitis: new insights into pathogenesis and mechanisms
Nature Reviews Gastroenterology & Hepatology 2016cited by 598position: lastdoi
The Future of Basic Science in Academic Surgery
Annals of Surgery 2016cited by 187position: middledoi
The human milk oligosaccharide 2′-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine
British Journal Of Nutrition 2016cited by 181position: lastdoi
Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents
Journal of Neuroscience 2016cited by 82position: middledoi
Toll-like receptor 4–mediated lymphocyte influx induces neonatal necrotizing enterocolitis
Journal of Clinical Investigation 2015cited by 232position: lastdoi
Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor
Mucosal Immunology 2015cited by 225position: lastdoi
Intestinal Stem Cell Growth and Differentiation on a Tubular Scaffold with Evaluation in Small and Large Animals
Regenerative Medicine 2015cited by 95position: lastdoi
Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut
The Journal of Immunology 2015cited by 77position: lastdoi
Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice
Journal of Clinical Investigation 2015cited by 74position: middledoi
Synthetic small intestinal scaffolds for improved studies of intestinal differentiation
Biotechnology and Bioengineering 2014cited by 155position: middledoi
Intracellular Heat Shock Protein-70 Negatively Regulates TLR4 Signaling in the Newborn Intestinal Epithelium
The Journal of Immunology 2012cited by 89position: lastdoi
Novel Role for the Innate Immune Receptor Toll-Like Receptor 4 (TLR4) in the Regulation of the Wnt Signaling Pathway and Photoreceptor Apoptosis
PLoS ONE 2012cited by 76position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Hongpeng Jia · Johns Hopkins Medicine10 papers (2012–2020)Chhinder P. Sodhi · Johns Hopkins University9 papers (2015–2022)Thomas Prindle · Johns Hopkins Medicine7 papers (2012–2020)Yukihiro Yamaguchi · Virginia Commonwealth University7 papers (2015–2020)Chhinder P. Sodhi · Johns Hopkins Medicine5 papers (2012–2015)William B. Fulton · Johns Hopkins Medicine5 papers (2015–2020)Misty Good · University of North Carolina at Chapel Hill5 papers (2012–2016)John A. Ozolek · University of Pittsburgh Medical Center5 papers (2012–2016)Diego F. Niño · Florida International University5 papers (2015–2020)Peng Lü · Fudan University4 papers (2015–2020)Qinjie Zhou · Qingdao University3 papers (2016–2020)Maria Branca · University of Pittsburgh Medical Center3 papers (2012–2015)Sanxia Wang · Johns Hopkins Medicine3 papers (2017–2020)Shahab Shaffiey · Twitter (United States)3 papers (2014–2018)Timothy R. Billiar · Institute for Transfusion Medicine3 papers (2015–2016)Congrong Ma · UPMC Hillman Cancer Center3 papers (2012–2016)Peng Lu · Nantong University2 papers (2015–2018)Laura Y. Martin · Johns Hopkins Medicine2 papers (2016–2018)Matthew H. Levine · Broad Institute2 papers (2016–2018)Amin Afrazi · University of Pittsburgh Medical Center2 papers (2012–2015)