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Lei Chang

Jiangnan University · CN
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Area of research
Molecular Biology · Spectroscopy
Research interest
Research interests include Ubiquitin and proteasome pathways, Advanced Proteomics Techniques and Applications, Advanced Biosensing Techniques and Applications, and Cancer-related molecular mechanisms research.
h-index
40
citations
6,951
works
176
NIH funding
primary concept
email

Recent publications

Sensitive and Deep Coverage Phosphoproteome Detection Method Reveals Spleen as a More Sensitive Organ than Liver in Early Detection of Liver Fibrosis-Related Signaling Protein Dysregulation
Analytical Chemistry 2025cited by 6position: middledoi
Phosphoproteomics delineates hepatocellular carcinoma subtypes and pinpoints therapeutic targets
Hepatology 2025cited by 6position: middledoi
Phosphoproteomics delineates hepatocellular carcinoma subtypes and pinpoints therapeutic targets.
2025cited by 3position: contributordoi
Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine
Journal of Ethnopharmacology 2025cited by 2position: middledoi
Exosomal Proteome from Hepatocellular Carcinoma Patient-Derived Xenograft Mice Serves as Identity of Liver Cancer
Journal of Proteome Research 2025cited by 1position: middledoi
Shotgun and targeted proteomics of Mycolicibacterium smegmatis highlight the role of arginine phosphorylation in the functional adaptation to its environment
Journal of Proteomics 2025cited by 1position: middledoi
Quantitative Proteome Analysis of Plasma Extracellular Vesicles Identifies Three Proteins with Potential Diagnostic Value for <i>Mycobacterium bovis</i> Infection in Cows
Journal of Proteome Research 2025cited by 0position: middledoi
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
Nature Biotechnology 2024cited by 52position: firstdoi
Proteome overview of exosome derived from plasma of cows infected with Mycobacterium bovis
Tuberculosis 2024cited by 2position: middledoi
Mycobacterium tuberculosis short mutant H37Rv-S with reduced growth adaptability is more readily recognized by the host immune system
Microbial Pathogenesis 2024cited by 2position: middledoi
Addendum: Cellular differentiation into hyphae and spores in halophilic archaea
Nature Communications 2024cited by 0position: middledoi
Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis
Gastroenterology 2023cited by 50position: middledoi
Development and multi-center validation of a fully automated digital immunoassay for neurofilament light chain: toward a clinical blood test for neuronal injury
Clinical Chemistry and Laboratory Medicine (CCLM) 2023cited by 21position: middledoi
Cellular differentiation into hyphae and spores in halophilic archaea
Nature Communications 2023cited by 16position: middledoi
Damaged collagen detected by collagen hybridizing peptide as efficient diagnosis marker for early hepatic fibrosis
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2023cited by 11position: middledoi
Using transcriptomics, proteomics and phosphoproteomics as new approach methodology (NAM) to define biological responses for chemical safety assessment
Chemosphere 2022cited by 26position: middledoi
iTRAQ-based proteomic analysis of Deinococcus radiodurans in response to 12C6+ heavy ion irradiation
BMC Microbiology 2022cited by 6position: middledoi
Mirror proteases of Ac-Trypsin and Ac-LysargiNase precisely improve novel event identifications in Mycolicibacterium smegmatis MC2 155 by proteogenomic analysis
Frontiers in Microbiology 2022cited by 6position: middledoi
Serum extracellular vesicle proteome differentiate early stage liver fibrosis
International Journal of Mass Spectrometry 2022cited by 3position: middledoi
Chemically labeled ThUBD permits rapid and super-sensitive imaging of polyubiquitination signals
The Analyst 2022cited by 3position: middledoi
The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration
2022cited by 2position: contributordoi
Additional file 2 of iTRAQ-based proteomic analysis of Deinococcus radiodurans in response to 12C6+ heavy ion irradiation
Open MIND 2022cited by 0position: middledoi
Using NAMs to characterize chemical bioactivity at the transcriptomic, proteomic and phosphoproteomic levels
2022cited by 0position: contributordoi
Serum-Derived Exosomal Proteins as Potential Candidate Biomarkers for Hepatocellular Carcinoma
ACS Omega 2021cited by 47position: middledoi
Quantitative proteomics reveals that dormancy-related proteins mediate the attenuation in mycobacterium strains
Figshare 2021cited by 0position: middledoi
Quantitative proteomics reveals that dormancy-related proteins mediate the attenuation in mycobacterium strains
Figshare 2021cited by 0position: middledoi
Reticulon 3-mediated Chk2/p53 activation suppresses hepatocellular carcinogenesis and is blocked by hepatitis B virus
Gut 2020cited by 56position: middledoi
Quantitative Proteomics Reveals the Development of HBV-Associated Glomerulonephritis Triggered by the Downregulation of SLC7A7
Journal of Proteome Research 2020cited by 9position: middledoi
Ubiquitin Linkage Specificity of Deubiquitinases Determines Cyclophilin Nuclear Localization and Degradation
iScience 2020cited by 9position: middledoi
Serum protein complex profiling reveals heterogeneity of Balanced constitutional population in traditional Chinese medicine through blue native polyacrylamide gel electrophoresis
Annals of Palliative Medicine 2020cited by 2position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Ping Xu · Chengdu University20 papers (2015–2025)Yanchang Li · Anhui Medical University14 papers (2015–2025) · 8 papers (2021–2025)Tao Zuo · University of Alabama at Birmingham8 papers (2020–2025)Jiahui Shi · Hunan University6 papers (2021–2025)Hangfan Zhou · Ministry of Education of the People's Republic of China5 papers (2022–2025)Junzhu Wu · Fudan University5 papers (2015–2022)Zhenpeng Zhang · Jiangsu University4 papers (2022–2022)Yuan Gao · Yale Cancer Center4 papers (2019–2022)Weidi Xiao · Ministry of Education of the People's Republic of China3 papers (2019–2022)Tao Zhang · Nanchang University3 papers (2020–2025)Yao Zhang · Tianjin University of Traditional Chinese Medicine3 papers (2021–2025)Fuqiang Wang · Nanchang University3 papers (2019–2020)Jinshuai Sun · Xinjiang University3 papers (2019–2021)Yuanyuan Ruan · Fudan University3 papers (2019–2023)Wenhui Wu · Guangzhou University of Chinese Medicine3 papers (2022–2025)Erhei Dai · Hebei Medical University3 papers (2021–2022)Tao Zuo · Elsevier, Inc.3 papers (2022–2025)Kaixuan Li · Ministry of Education of the People's Republic of China3 papers (2022–2025)Ping Xu · Peking University Third Hospital3 papers (2022–2025)
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