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Guanghua Lei

Ministry of Education of the People's Republic of China · CN
Area of research
Rheumatology · Surgery
Research interest
Research interests include Osteoarthritis Treatment and Mechanisms, Total Knee Arthroplasty Outcomes, Knee injuries and reconstruction techniques, and Rheumatoid Arthritis Research and Therapies.
h-index
46
citations
8,160
works
315
NIH funding
primary concept
Medicine
email

Recent publications

Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling
Science 2025cited by 89position: lastdoi
Sequential Targeting Chondroitin Sulfate‐Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages
Advanced Science 2025cited by 21position: middledoi
The X-Age Project to construct a Chinese aging clock
Nature Aging 2025cited by 9position: middledoi
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3
Science Advances 2025cited by 8position: middledoi
Sarcopenia and Risk of Cognitive Impairment: Cohort Study and Mendelian Randomization Analysis
JMIR Aging 2025cited by 6position: middledoi
Target Serum Urate Achievement and Chronic Kidney Disease Progression in Patients With Gout and Kidney Disease
JAMA Internal Medicine 2024cited by 29position: middledoi
Denosumab and incidence of type 2 diabetes among adults with osteoporosis: population based cohort study
BMJ 2023cited by 58position: middledoi
Genetic Variants, Serum 25-Hydroxyvitamin D Levels, and Sarcopenia
JAMA Network Open 2023cited by 47position: lastdoi
The gut microbiome-joint axis in osteoarthritis
Science Bulletin 2023cited by 41position: lastdoi
Burden and Characteristics of Revision Total Knee Arthroplasty in China: A National Study Based on Hospitalized Cases
The Journal of Arthroplasty 2023cited by 17position: middledoi
A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium
Life Medicine 2023cited by 17position: middledoi
Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension
European Heart Journal 2022cited by 26position: middledoi
Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis
Annals of the Rheumatic Diseases 2021cited by 53position: middledoi
Guidelines for the diagnosis and treatment of osteoarthritis in China (2019 edition)
Annals of Translational Medicine 2020cited by 167position: middledoi
Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior
Arthritis Research & Therapy 2020cited by 88position: lastdoi
Knee Osteoarthritis, Potential Mediators, and Risk of All‐Cause Mortality: Data From the Osteoarthritis Initiative
Arthritis Care & Research 2020cited by 71position: middledoi
Association of Tramadol Use With Risk of Hip Fracture
Journal of Bone and Mineral Research 2020cited by 34position: middledoi
Development and formulation of the classification criteria for osteoarthritis
Annals of Translational Medicine 2020cited by 12position: middledoi
Erratum to development and formulation of the classification criteria for osteoarthritis
Annals of Translational Medicine 2020cited by 1position: middledoi
Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis
JAMA 2019cited by 261position: middledoi
Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative
Osteoarthritis and Cartilage 2019cited by 219position: middledoi
Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis
Arthritis Research & Therapy 2017cited by 61position: lastdoi
Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiation
Cell Death and Disease 2014cited by 116position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Chao Zeng · Central South University17 papers (2017–2025)Jie Wei · Weifang People's Hospital15 papers (2017–2025)Yilun Wang · Ministry of Education of the People's Republic of China6 papers (2017–2025)Yuqing Zhang · Harvard University6 papers (2020–2025)Hui Li · Jinan University5 papers (2017–2025)Hyon K. Choi · Boston University4 papers (2017–2020)Nancy E. Lane · University of California, Davis4 papers (2019–2023)Changjun Li · University of Science and Technology Liaoning3 papers (2023–2025)Dongxing Xie · Ministry of Education of the People's Republic of China3 papers (2017–2025)Robert Terkeltaub · University of California San Diego3 papers (2017–2024)David J. Hunter · Shanghai Sixth People's Hospital3 papers (2017–2023)Na Lu · Tianjin University of Traditional Chinese Medicine3 papers (2019–2020)Yuxiao Chen · Dalian Medical University2 papers (2025–2025)Xiaoxiao Li · Southwestern Medical Center2 papers (2023–2024)Xuan Zhao · Nantong University2 papers (2025–2025)Xiang Ding · New York University2 papers (2020–2021) · 2 papers (2020–2025)Caifeng Deng · Hunan University2 papers (2025–2025)Tingting Sha · Ministry of Education of the People's Republic of China2 papers (2023–2025)Maureen Dubreuil · Boston University2 papers (2019–2020)