Area of research
Spectroscopy · Molecular Biology
Research interest
Research interests include Advanced Proteomics Techniques and Applications, Mass Spectrometry Techniques and Applications, Protein Degradation and Inhibitors, and Lung Cancer Treatments and Mutations.
Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.
Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2
Template-assisted covalent modification underlies activity of covalent molecular glues
APIR: Aggregating Universal Proteomics Database Search Algorithms for Peptide Identification with FDR Control.
Leveraging HILIC/ERLIC Separations for Online Nanoscale LC-MS/MS Analysis of Phosphopeptide Isoforms from RNA Polymerase II C-terminal Domain
Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia
Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway
Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway.
Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase
APIR: Aggregating Universal Proteomics Database Search Algorithms for Peptide Identification with FDR Control
Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism
Discovery and Structure–Activity Relationship Study of ( <i>Z</i> )-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors
Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes
Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding
Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.
Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype
Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis
SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification
MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia
Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C
Hepatic Dysfunction Caused by Consumption of a High-Fat Diet
Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
Alternative Splicing of MBD2 Supports Self-Renewal in Human Pluripotent Stem Cells