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Mikko Seppänen

University of Helsinki · FI
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Area of research
Immunology · Genetics
Research interest
Research interests include Immunodeficiency and Autoimmune Disorders, Blood disorders and treatments, Immune Cell Function and Interaction, and T-cell and B-cell Immunology.
h-index
49
citations
14,261
works
217
NIH funding
primary concept
email

Recent publications

Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee
Journal of Human Immunity 2025cited by 217position: middledoi
The 2024 update of IUIS phenotypic classification of human inborn errors of immunity
Journal of Human Immunity 2025cited by 108position: middledoi
SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency
The Journal of Experimental Medicine 2024cited by 20position: middledoi
A deep intronic splice–altering <i>AIRE</i> variant causes APECED syndrome through antisense oligonucleotide-targetable pseudoexon inclusion
Science Translational Medicine 2024cited by 10position: middledoi
JAK inhibitor treatment for inborn errors of JAK/STAT signaling: An ESID/EBMT-IEWP retrospective study
Journal of Allergy and Clinical Immunology 2023cited by 57position: middledoi
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
The Journal of Experimental Medicine 2023cited by 56position: middledoi
The GAIN Registry — a New Prospective Study for Patients with Multi-organ Autoimmunity and Autoinflammation
Journal of Clinical Immunology 2023cited by 9position: middledoi
Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee
Journal of Clinical Immunology 2022cited by 1,127position: middledoi
The 2022 Update of IUIS Phenotypical Classification for Human Inborn Errors of Immunity
Journal of Clinical Immunology 2022cited by 481position: middledoi
Studying severe long COVID to understand post-infectious disorders beyond COVID-19
Nature Medicine 2022cited by 143position: middledoi
STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation
Immunity 2022cited by 65position: middledoi
Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin
Science 2022cited by 64position: middledoi
Long-term follow up of families with pathogenic NFKB1 variants reveals incomplete penetrance and frequent inflammatory sequelae
Clinical Immunology 2022cited by 22position: lastdoi
Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis
Journal of Clinical Immunology 2022cited by 12position: middledoi
The Ever-Increasing Array of Novel Inborn Errors of Immunity: an Interim Update by the IUIS Committee
Journal of Clinical Immunology 2021cited by 213position: middledoi
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection
Cell 2020cited by 234position: middledoi
Global systematic review of primary immunodeficiency registries
Expert Review of Clinical Immunology 2020cited by 137position: middledoi
Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations
Journal of Allergy and Clinical Immunology 2020cited by 125position: middledoi
Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis
Journal of Clinical Immunology 2020cited by 18position: middledoi
Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score
Journal of Allergy and Clinical Immunology 2019cited by 156position: middledoi
Rubella Virus-Associated Cutaneous Granulomatous Disease: a Unique Complication in Immune-Deficient Patients, Not Limited to DNA Repair Disorders
Journal of Clinical Immunology 2019cited by 82position: middledoi
Novel TMEM173 Mutation and the Role of Disease Modifying Alleles
Frontiers in Immunology 2019cited by 68position: middledoi
Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy
Journal of Allergy and Clinical Immunology 2019cited by 55position: lastdoi
Diagnostics of rare disorders: whole-exome sequencing deciphering locus heterogeneity in telomere biology disorders
Orphanet Journal of Rare Diseases 2018cited by 11position: middledoi
Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes
Journal of Allergy and Clinical Immunology 2017cited by 120position: lastdoi
Unexpectedly High Prevalence of Common Variable Immunodeficiency in Finland
Frontiers in Immunology 2017cited by 68position: lastdoi
Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
Blood 2014cited by 276position: middledoi
The evolution of cellular deficiency in GATA2 mutation
Blood 2013cited by 213position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Christoph Klein · Freie Universität Berlin6 papers (2019–2025)Helen C. Su · ActionAid5 papers (2021–2025)Charlotte Cunningham‐Rundles · Child Health and Development Institute5 papers (2021–2025)Isabelle Meyts · KU Leuven5 papers (2021–2025)Tomohiro Morio · Rockefeller University5 papers (2021–2025) · 5 papers (2021–2025)Anne Puel · Inserm5 papers (2021–2025)Capucine Pïcard · Hôpital Necker-Enfants Malades5 papers (2021–2025)Janna Saarela · University of Helsinki5 papers (2017–2022)Troy R. Torgerson · Allen Institute for Immunology5 papers (2021–2025)Stuart G. Tangye · Garvan Institute of Medical Research5 papers (2021–2025)Kathleen E. Sullivan · Temple University4 papers (2019–2022)Juha Kere · University of Helsinki3 papers (2017–2022) · 3 papers (2021–2022) · 3 papers (2021–2022)Jennifer M. Puck · UCSF Benioff Children's Hospital3 papers (2021–2022) · 3 papers (2017–2022)Steven M. Holland · Amsterdam University Medical Centers3 papers (2021–2022)José Luis Franco · Rockefeller University3 papers (2021–2022)Ulla Wartiovaara‐Kautto · University of Helsinki2 papers (2018–2022)
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