Area of research
Cell Biology · Molecular Biology
Research interest
Research focused on Proteostasis and Cell biology, with related work in Unfolded protein response, ATF6, Transthyretin. Notable publications include 'Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics', 'Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation', and 'The unfolded protein response regulator ATF6 promotes mesodermal differentiation'.
Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation
Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation
ATF6 protects against protein misfolding during cardiac hypertrophy
Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation
Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation
DELE1 oligomerization promotes integrated stress response activation
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses
ATF6 is essential for human cone photoreceptor development
Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
The unfolded protein response regulator ATF6 promotes mesodermal differentiation
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1
Induced Pluripotent Stem Cell Modeling of Multisystemic, Hereditary Transthyretin Amyloidosis