Area of research
Genetics · Molecular Biology
Research interest
Research interests include Estrogen and related hormone effects, Genomics and Chromatin Dynamics, Computational Drug Discovery Methods, and Breast Cancer Treatment Studies.
Evaluating progesterone receptor agonist megestrol plus letrozole for women with early-stage estrogen-receptor-positive breast cancer: the window-of-opportunity, randomized, phase 2b, PIONEER trial
Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs
Genomic and spatial analysis of local recurrences following risk-adapted breast radiotherapy in the IMPORT trials
MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody–drug conjugates
Transcription factor switching drives subtype-specific pancreatic cancer
JAK2 signalling to HNRNPA1 represses retrotransposon activity in haematopoietic stem cells
EndoCompass project: research roadmap for endocrine causes and consequences of cancer
Towards a glutathione-cleavable azobenzene linker for antibody–drug conjugates
EndoCompass Project: Research Roadmap for Endocrine Causes and Consequences of Cancers
Towards the Targeted Protein Degradation of PRMT1
Abstract PO5-22-04: Genomic analysis of local recurrences following risk adapted breast radiotherapy in the IMPORT trials defines 'true recurrences' and 'new primaries'
Abstract C076: New insights into the role of FOXA1- HNF4 axis in pancreatic cancer
Abstract PS15-06: Results of the window-of-opportunity PIONEER trial evaluating addition of the progesterone receptor (PR) agonist megestrol to letrozole for early stage estrogen receptor (ER) positive breast cancer: exploiting ER-PR interaction
Inhibition of AR and DNA-PK for radio-sensitization of AR-driven cancers.
The EstroGene Database Reveals Diverse Temporal, Context-Dependent, and Bidirectional Estrogen Receptor Regulomes in Breast Cancer
FOXA1 Reprogramming Dictates Retinoid X Receptor Response in <i>ESR1</i> -Mutant Breast Cancer
Data from Nkx3-1 and LEF-1 Function as Transcriptional Inhibitors of Estrogen Receptor Activity
Data from Hotspot <i>ESR1</i> Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis
Data from <i>FOXA1</i> Is a Potential Oncogene in Anaplastic Thyroid Carcinoma
Data from <i>FOXA1</i> Is a Potential Oncogene in Anaplastic Thyroid Carcinoma
Data from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer
Data from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer
Hotspot <i>ESR1</i> Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis
The proneural transcription factor ASCL1 regulates cell proliferation and primes for differentiation in neuroblastoma
A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer
Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer
Abstract OT2-19-01: Presurgical treatment with ribociclib and letrozole in patients with locally advanced breast cancer: The NEOLETRIB study
The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer
TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions
Rapid and robust cysteine bioconjugation with vinylheteroarenes