Area of research
Molecular Biology · Physiology
Research interest
Research interests include Ion channel regulation and function, Calcium signaling and nucleotide metabolism, Cardiac electrophysiology and arrhythmias, and Neuroscience and Neuropharmacology Research.
Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload
Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel
Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1
Structural mechanisms of assembly, gating, and calmodulin modulation of human olfactory CNG channel
TRPML1 gating modulation by allosteric mutations and lipids
Structural mechanism of proton conduction in otopetrin proton channel
Structural mechanisms of human sodium-coupled high-affinity choline transporter CHT1
TRPML1 gating modulation by allosteric mutations and lipids (Design of allosteric mutations that recapitulate the gating of TRPML1)
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel
Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1
Structure and Function of Plant and Mammalian TPC Channels
Structural mechanisms of gating and selectivity of human rod CNGA1 channel
Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel
TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase
Structural biology of cation channels important for lysosomal calcium release
Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations
Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter
Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter
Structural mechanisms of phospholipid activation of the human TPC2 channel
Ca2+-regulated Ca2+ channels with an RCK gating ring control plant symbiotic associations
Structural and functional characterization of an otopetrin family proton channel
Publisher Correction: Ca2+-regulated Ca2+ channels with an RCK gating ring control plant symbiotic associations
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
Cryo-EM structure of a fungal mitochondrial calcium uniporter
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
Tuning the ion selectivity of two-pore channels
The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture
Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger
Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology
Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana