Area of research
Oncology · Surgery
Research interest
Research focused on Cholestasis and Hepatocyte, with related work in Primary sclerosing cholangitis, Immunology, Carcinogenesis. Notable publications include 'Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms...', 'Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19', and 'Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS'.
Cell type specific decoding of TGF-β2 production, signaling and outcome in the dynamics of cholestatic liver disease
Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON)
Systematic assessment of COVID-19 host genetics using whole genome sequencing data
Sublethal necroptosis signaling promotes inflammation and liver cancer
Semaphorin 3C exacerbates liver fibrosis
Study protocol of an open-label, single arm phase II trial investigating the efficacy and safety of Trifluridine/Tipiracil combined with irinotecan as a second line therapy in patients with cholangiocarcinoma (TRITICC)
Atezolizumab Plus Bevacizumab in Patients with Advanced and Progressing Hepatocellular Carcinoma: Retrospective Multicenter Experience
FOLFOX plus panitumumab or FOLFOX alone as additive therapy following R0/1 resection of RAS wild-type colorectal cancer liver metastases – The PARLIM trial (AIO KRK 0314)
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis
Diagnosis and management of secondary causes of steatohepatitis
Spontaneous Cholemia in C57BL/6 Mice Predisposes to Liver Cancer in NASH
JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging
IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expression
Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood
Phenotypic spectrum and diagnostic pitfalls of ABCB4 deficiency depending on age of onset
Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice
Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection
Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants
Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family
Bile salt export pump‐reactive antibodies form a polyclonal, multi‐inhibitory response in antibody‐induced bile salt export pump deficiency
Characterization of animal models for primary sclerosing cholangitis (PSC)
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
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