Area of research
Molecular Biology · Neurology
Research interest
Research interests include Prion Diseases and Protein Misfolding, Neurological diseases and metabolism, Trace Elements in Health, and RNA regulation and disease.
Chaperone-mediated disaggregation of infectious prions releases particles that seed new prion formation in a strain-specific manner
Evidence against efficient spontaneous disassembly of prions into small oligomers
Grp78 destabilization of infectious prions is strain-specific and modified by multiple factors including accessory chaperones and pH
The PINK1/Parkin pathway of mitophagy exerts a protective effect during prion disease.
Cell biology of prion strains in vivo and in vitro.
Lack of the immune adaptor molecule SARM1 accelerates disease in prion infected mice and is associated with increased mitochondrial respiration and decreased expression of NRF2.
The Size and Stability of Infectious Prion Aggregates Fluctuate Dynamically during Cellular Uptake and Disaggregation.
β-Barrel proteins tether the outer membrane in many Gram-negative bacteria
Transmission characteristics of heterozygous cases of Creutzfeldt-Jakob disease with variable abnormal prion protein allotypes.
Altered distribution, aggregation, and protease resistance of cellular prion protein following intracranial inoculation.