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W. Marston Linehan

Harvard University · US
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Area of research
Pulmonary and Respiratory Medicine · Molecular Biology
Research interest
Research interests include Renal and related cancers, Lung Cancer Treatments and Mutations, Cancer, Hypoxia, and Metabolism, and Renal cell carcinoma treatment.
h-index
78
citations
40,456
works
472
NIH funding
primary concept
Medicine
email

Recent publications

Belzutifan for von Hippel-Lindau disease-associated renal cell carcinoma and other neoplasms (LITESPARK-004): 50 months follow-up from a single-arm, phase 2 study
The Lancet Oncology 2025cited by 23position: middledoi
Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma
Nature Communications 2025cited by 6position: middledoi
Repotrectinib in <i>ROS1</i> Fusion–Positive Non–Small-Cell Lung Cancer
New England Journal of Medicine 2024cited by 205position: middledoi
Consolidation Osimertinib Versus Durvalumab Versus Observation After Concurrent Chemoradiation in Unresectable EGFR-Mutant NSCLC: A Multicenter Retrospective Cohort Study
Journal of Thoracic Oncology 2024cited by 38position: middledoi
Belzutifan for patients with von Hippel-Lindau disease-associated CNS haemangioblastomas (LITESPARK-004): a multicentre, single-arm, phase 2 study
The Lancet Oncology 2024cited by 35position: middledoi
1256MO Phase I/II ARROS-1 study of zidesamtinib (NVL-520) in ROS1 fusion-positive solid tumours
Annals of Oncology 2024cited by 18position: lastdoi
Oral Hypoxia-Inducible Factor 2α Inhibitor Belzutifan in Ocular von Hippel-Lindau Disease
Ophthalmology 2024cited by 14position: middledoi
Consolidation ALK Tyrosine Kinase Inhibitors Versus Durvalumab or Observation After Chemoradiation in Unresectable Stage III ALK-Positive NSCLC
Journal of Thoracic Oncology 2024cited by 11position: middledoi
Genome-Wide Analysis Identifies Nuclear Factor 1C as a Novel Transcription Factor and Potential Therapeutic Target in SCLC
Journal of Thoracic Oncology 2024cited by 8position: middledoi
766P A phase II trial of fuzuloparib in combination with apatinib vs. fuzuloparib alone for recurrent ovarian cancer (OC)
Annals of Oncology 2024cited by 2position: middledoi
Reprogramming tumour-associated macrophages to outcompete cancer cells
Nature 2023cited by 138position: middledoi
Clinicopathologic and Genomic Factors Impacting Efficacy of First-Line Chemoimmunotherapy in Advanced NSCLC
Journal of Thoracic Oncology 2023cited by 91position: middledoi
1372P Repotrectinib in patients (pts) with NTRK fusion-positive (NTRK+) advanced solid tumors, including NSCLC: Update from the phase I/II TRIDENT-1 trial
Annals of Oncology 2023cited by 53position: middledoi
668P Efficacy and safety of larotrectinib in a pooled analysis of patients (Pts) with tropomyosin receptor kinase (TRK) fusion cancer
Annals of Oncology 2023cited by 5position: middledoi
666P Updated efficacy and safety data of entrectinib in patients (pts) with locally advanced/metastatic NTRK fusion-positive (fp) solid tumours
Annals of Oncology 2023cited by 4position: middledoi
Abstract CT228: Concordance between tissue and circulating tumor DNA (ctDNA) testing for neurotrophic tyrosine receptor kinase (<i>NTRK</i>) gene fusions in larotrectinib (laro) clinical trials
Cancer Research 2023cited by 2position: middledoi
Safety and efficacy of pralsetinib in RET fusion–positive non-small-cell lung cancer including as first-line therapy: update from the ARROW trial
Annals of Oncology 2022cited by 175position: middledoi
Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma
The Medicine Forum 2022cited by 124position: middle
Brief Report: Chylothorax and Chylous Ascites During RET Tyrosine Kinase Inhibitor Therapy
Journal of Thoracic Oncology 2022cited by 45position: lastdoi
Pivotal topline data from the phase 1/2 TRIDENT-1 trial of repotrectinib in patients with ROS1+ advanced non-small cell lung cancer (NSCLC)
European Journal of Cancer 2022cited by 17position: middledoi
Safety and preliminary clinical activity of NVL-520, a highly selective ROS1 inhibitor, in patients with advanced ROS1 fusion-positive solid tumors
European Journal of Cancer 2022cited by 11position: lastdoi
463P Efficacy and safety of larotrectinib in a pooled analysis of patients (Pts) with tropomyosin receptor kinase (TRK) fusion cancer with an extended follow-up
Annals of Oncology 2022cited by 1position: middledoi
464P Intra-patient (Pt) comparison from larotrectinib (Laro) clinical trials in tropomyosin receptor kinase (TRK) fusion cancer: An expanded dataset
Annals of Oncology 2022cited by 1position: middledoi
Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status
Journal of Thoracic Oncology 2021cited by 363position: middledoi
534P Larotrectinib in non-CNS TRK fusion cancer patients: Outcomes by prior therapy and performance status
Annals of Oncology 2021cited by 0position: middledoi
RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies
Journal of Thoracic Oncology 2020cited by 280position: middledoi
Mechanisms of resistance to selective RET tyrosine kinase inhibitors in RET fusion-positive non-small-cell lung cancer
Annals of Oncology 2020cited by 225position: firstdoi
Phase II study of the oral HIF-2α inhibitor MK-6482 for Von Hippel-Lindau disease–associated renal cell carcinoma.
Journal of Clinical Oncology 2020cited by 42position: middledoi
Safety and preliminary clinical activity of repotrectinib in patients with advanced ROS1/TRK fusion-positive solid tumors (TRIDENT-1 study)
Annals of Oncology 2019cited by 18position: middledoi
Frequency of Brain Metastases and Multikinase Inhibitor Outcomes in Patients With RET–Rearranged Lung Cancers
Journal of Thoracic Oncology 2018cited by 230position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Alexander Drilon · Université Grenoble Alpes13 papers (2018–2024)David S. Hong · The University of Texas MD Anderson Cancer Center6 papers (2021–2023)Theodore W. Laetsch · Children's Hospital of Philadelphia5 papers (2021–2023)Ray McDermott · University College Dublin5 papers (2021–2023)Ulrik Lassen · Institut Bergonié5 papers (2021–2023)Viola W. Zhu · Covalent Associates (United States)5 papers (2018–2024)Shivaani Kummar · Stanford University4 papers (2021–2023)Tobias Else · University of Michigan4 papers (2020–2025) · 4 papers (2022–2023)Benjamin L. Maughan · University of Utah4 papers (2020–2025)Jodi K. Maranchie · Center for Cancer Research4 papers (2020–2025)François Doz · Institut Curie4 papers (2021–2023) · 4 papers (2021–2023)Rodolfo F. Perini · Merck & Co., Inc., Rahway, NJ, USA (United States)4 papers (2020–2025)Justin F. Gainor · Harvard University4 papers (2018–2022)D. Ross Camidge · University of Colorado Anschutz Medical Campus4 papers (2018–2024)Catherine M. Albert · University of Washington3 papers (2021–2023)Daniel Shao-Weng Tan · Cone Health3 papers (2020–2023) · 3 papers (2024–2025)Marcia S. Brose · Thomas Jefferson University3 papers (2022–2023)
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