Area of research
Aging · Cell Biology
Research interest
Research focused on Proteotoxicity and Caenorhabditis elegans, with related work in Proteostasis, Neurodegeneration, Cell biology. Notable publications include 'A novel inhibitor of the insulin/IGF signaling pathway protects from age‐onset, neurodegeneration‐linked proteotoxicity', 'A Neuronal GPCR is Critical for the Induction of the Heat Shock Response in the Nematode C. elegans', and 'Organismal Protein Homeostasis Mechanisms'.
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling
TGF-β signaling as an organismal proteostasis regulator
The killifish germline regulates longevity and somatic repair in a sex-specific manner
Cathepsin B promotes Aβ proteotoxicity by modulating aging regulating mechanisms
Regulation of the proteostasis network by the neuronal system
A short peptide protects from <scp>age‐onset</scp> proteotoxicity
Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults
Temporal requirements of SKN-1/NRF as a regulator of lifespan and proteostasis in Caenorhabditis elegans
Organismal Protein Homeostasis Mechanisms
Exploring Alzheimer’s Disease Molecular Variability via Calculation of Personalized Transcriptional Signatures
Expanded CUG Repeats Trigger Disease Phenotype and Expression Changes through the RNAi Machinery in C. elegans
Gene expression modulation by the linker of nucleoskeleton and cytoskeleton complex contributes to proteostasis
Lipid Assemblies at the Crossroads of Aging, Proteostasis, and Neurodegeneration
Modulation of caveolae by insulin/IGF‐1 signaling regulates aging of Caenorhabditis elegans
The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans
Self-assembly of a metallo-peptide into a drug delivery system using a “switch on” displacement strategy
A multi-animal tracker for studying complex behaviors
The Emerging Roles of Early Protein Folding Events in the Secretory Pathway in the Development of Neurodegenerative Maladies
Vesicle‐mediated secretion of misfolded prion protein molecules from cyclosporin A‐treated cells
PrP-containing aggresomes are cytosolic components of an ER quality control mechanism
Alzheimer's disease‐causing proline substitutions lead to presenilin 1 aggregation and malfunction
The inhibition of IGF‐1 signaling promotes proteostasis by enhancing protein aggregation and deposition
Proteostasis collapse, inter-tissue communication, and the regulation of aging at the organismal level
Differential Regulation of the Heat Shock Factor 1 and DAF-16 by Neuronal nhl-1 in the Nematode C. elegans
The Roles of Cellular and Organismal Aging in the Development of Late-Onset Maladies
The nematode Caenorhabditis elegans: A versatile model for the study of proteotoxicity and aging
Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders
A novel inhibitor of the insulin/IGF signaling pathway protects from age‐onset, neurodegeneration‐linked proteotoxicity
A Neuronal GPCR is Critical for the Induction of the Heat Shock Response in the Nematode<i>C. elegans</i>
Temporal requirements of heat shock factor‐1 for longevity assurance