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Wesley R. Legant

University of North Carolina at Chapel Hill · US
Area of research
Biophysics · Cell Biology
Research interest
Research interests include Advanced Fluorescence Microscopy Techniques, Cellular Mechanics and Interactions, Cell Image Analysis Techniques, and 3D Printing in Biomedical Research.
h-index
32
citations
10,773
works
98
NIH funding
primary concept
email

Recent publications

Smart lattice light-sheet microscopy for imaging rare and complex cellular events
Nature Methods 2024cited by 62position: lastdoi
Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment
Nature Communications 2024cited by 27position: lastdoi
A series of spontaneously blinking dyes for super-resolution microscopy
Nature Methods 2024cited by 26position: middledoi
Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics
Acta Biomaterialia 2023cited by 11position: middledoi
Superresolution microscopy reveals actomyosin dynamics in medioapical arrays
Molecular Biology of the Cell 2022cited by 4position: middledoi
Phase separation drives aberrant chromatin looping and cancer development
Nature 2021cited by 458position: middledoi
3D ATAC-PALM: super-resolution imaging of the accessible genome
Nature Methods 2020cited by 83position: middledoi
Augmin accumulation on long-lived microtubules drives amplification and kinetochore-directed growth
The Journal of Cell Biology 2019cited by 91position: middledoi
High-resolution imaging reveals how the spindle midzone impacts chromosome movement
The Journal of Cell Biology 2019cited by 67position: middledoi
Software for lattice light-sheet imaging of FRET biosensors, illustrated with a new Rap1 biosensor
The Journal of Cell Biology 2019cited by 44position: middledoi
Applying systems-level spectral imaging and analysis to reveal the organelle interactome
Nature 2017cited by 1,127position: middledoi
Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER
Science 2016cited by 485position: middledoi
High-density three-dimensional localization microscopy across large volumes
Nature Methods 2016cited by 311position: firstdoi
Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy
Molecular Biology of the Cell 2016cited by 159position: middledoi
Real-time imaging of Huntingtin aggregates diverting target search and gene transcription
eLife 2016cited by 108position: middledoi
Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication?
F1000Research 2016cited by 26position: middledoi
Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse
Immunity 2015cited by 317position: middledoi
Three-dimensional tracking of plus-tips by lattice light-sheet microscopy permits the quantification of microtubule growth trajectories within the mitotic apparatus
Journal of Biomedical Optics 2015cited by 62position: middledoi
Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells
Molecular Biology of the Cell 2015cited by 40position: middledoi
Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution
Science 2014cited by 2,045position: middledoi
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
Cell 2014cited by 646position: middledoi
3D imaging of Sox2 enhancer clusters in embryonic stem cells
eLife 2014cited by 279position: middledoi
Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels
Nature Materials 2013cited by 1,144position: middledoi
Carbofluoresceins and Carborhodamines as Scaffolds for High-Contrast Fluorogenic Probes
ACS Chemical Biology 2013cited by 225position: middledoi
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
Proceedings of the National Academy of Sciences 2012cited by 283position: firstdoi

Grants

CAREER: Connecting Physical Forces to Cell Migration Through Complex Environments
NSF2540625$615,0002026–2031PIRePORTER

Frequent collaborators

Eric Betzig · Howard Hughes Medical Institute17 papers (2012–2022)Luke D. Lavis · Howard Hughes Medical Institute7 papers (2013–2024)Zhe Liu · Guangzhou University of Chinese Medicine6 papers (2014–2024)Bi‐Chang Chen · Research Center for Applied Science, Academia Sinica6 papers (2014–2016)Jonathan B. Grimm · Howard Hughes Medical Institute5 papers (2013–2024) · 4 papers (2021–2024)Robert Tjian · Howard Hughes Medical Institute4 papers (2014–2020)Li Li · Wayne State University3 papers (2014–2016)Peng Dong · Howard Hughes Medical Institute3 papers (2016–2024)Jennifer Lippincott‐Schwartz · Northwestern University3 papers (2015–2017)Liangqi Xie · Cleveland Clinic2 papers (2020–2024)Dong Li · Chinese Academy of Sciences2 papers (2016–2022)Christopher S. Chen · Boston University2 papers (2012–2013)Liang Gao · California NanoSystems Institute2 papers (2012–2015)Alex T. Ritter · Emergency University2 papers (2015–2024)Lin Shao · Jiangnan University2 papers (2012–2016)Brian P. English · Howard Hughes Medical Institute2 papers (2020–2024)Gaudenz Danuser · Roche (Switzerland)2 papers (2016–2019)Raphaël Gaudin · University of Cape Town2 papers (2015–2016)Timothy A. Brown · South College2 papers (2016–2024)