Area of research
Behavioral Neuroscience · Endocrinology, Diabetes and Metabolism
Research interest
Hormones are crucial for health and disease. In our research we focus on the action of hormones released after stress. These stress hormones program in early life brain circuits that underly emotion and cognition, they protect the brain and regulate the ageing process. Stress hormones determine vulnerability and resilience to depression and schizophrenia depending on genetic predisposition, and are of importance for the onset and progression of neurodegenerative processes. To understand how this enormous diversity in action of stress hormones occurs a unique integrated experimental approach from gene to behaviour is used.
Science with Seymour Levine: on glucocorticoid action from birth to senescence.
The cortisol switch between vulnerability and resilience.
Coping with the multifaceted and multifunctional role of cortisol in the brain.
Edo Ronald de Kloet: How does the action of glucocorticoids change from protective to harmful? What is the cause? And what are the consequences?
The cortisol switch between vulnerability and resilience
Glucocorticoid feedback paradox: a homage to Mary Dallman.
Heartbeat of brain tumours targeted.
Forced swim stressor: Trends in usage and mechanistic consideration.
Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago: FOCUS ON cortisol, thyroid hormones, testosterone and GABA
Floating Rodents and Stress-Coping Neurobiology.
Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases.
Top-down and bottom-up control of stress-coping.
Resetting the Stress System with a Mifepristone Challenge.
Mineralocorticoid Receptors, Neuroinflammation and Hypertensive Encephalopathy.
Genetic variation of the mineralocorticoid receptor gene (MR, NR3C2) is associated with a conceptual endophenotype of "CRF-hypoactivity".
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
The three-hit concept of vulnerability and resilience: Toward understanding adaptation to early-life adversity outcome
Stress or no stress: Mineralocorticoid receptors in the forebrain regulate behavioral adaptation