Area of research
Physiology · Molecular Biology
Research interest
Research focused on Neuroscience and Disease, with related work in Transcriptome, Progressive supranuclear palsy, Tauopathy. Notable publications include 'Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease', 'Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus', and 'Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions'.
Mitochondrial complex I deficiency induces Alzheimer's disease–like signatures that are reversible by targeted therapy
The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development
Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease
Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer’s disease
The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal development
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90
A metabolomic signature of the APOE2 allele
Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease
Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions
A systems‐biology clinical trial of a personalized multimodal lifestyle intervention for early Alzheimer's disease
Microglia show differential transcriptomic response to Aβ peptide aggregates <i>ex vivo</i> and <i>in vivo</i>
Manifestations of Alzheimer’s Disease Genetic Risk in the Blood: A Cross-Sectional Multi-Omic Analysis in Healthy Adults Aged 18-90+
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions
Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models
Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease
Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data across 27 Tissue Types
Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Cholesterol Metabolism in Alzheimer’s Disease
Reproducible big data science: A case study in continuous FAIRness
Identifying differences in bile acid pathways for cholesterol clearance in Alzheimer’s disease using metabolic networks of human brain regions
Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus
Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases