Area of research
Cell Biology · Epidemiology
Research interest
Research interests include Endoplasmic Reticulum Stress and Disease, Pancreatic function and diabetes, Neuroendocrine Tumor Research Advances, and Autophagy in Disease and Therapy.
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis
ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR
ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis
Nicotinic acetylcholine receptor signaling regulates inositol-requiring enzyme 1α activation to protect β-cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress.
Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib.
Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes
Small Molecules to Improve ER Proteostasis in Disease
Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes.
Small Molecules to Improve ER Proteostasis in Disease.
Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress
Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.
Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress.
Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.
Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival
Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1.
Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival
Chaperone-Mediated Reflux of Secretory Proteins to the Cytosol During Endoplasmic Reticulum Stress
The Unfolded Protein Response and Cell Fate Control
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands
COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis
The Role of Endoplasmic Reticulum Stress in Human Pathology
Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress
Druggable sensors of the unfolded protein response
IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2
Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors