Area of research
Pharmacology · Molecular Biology
Research interest
Research interests include Microbial Natural Products and Biosynthesis, Plant biochemistry and biosynthesis, Fungal Biology and Applications, and Microbial Metabolism and Applications.
Synthetic Biology in Natural Product Biosynthesis
Copper-dependent halogenase catalyses unactivated C−H bond functionalization
Fungal RiPPs Side Chain Macrocyclization Catalyzed by Copper-Dependent DUF3328 Enzyme
Copper-Dependent Oxidase Catalyzes Aryl Cross-Coupling in the Biosynthesis of a Minimal Ribosomally Derived Natural Product
Tunable regiodivergent C–H alkenylation of 2-arylthiazoles <i>via</i> catalyst control
Structural Bases of Dihydroxy Acid Dehydratase Inhibition and Biodesign for Self-Resistance
Genome mining for unknown–unknown natural products
High-Throughput Identification of Crystalline Natural Products from Crude Extracts Enabled by Microarray Technology and microED
Biosynthesis of Polycyclic Natural Products from Conjugated Polyenes via Tandem Isomerization and Pericyclic Reactions
Assessing the Biosynthetic Inventory of the Biocontrol Fungus <i>Trichoderma afroharzianum</i> T22
Genome Mining from Agriculturally Relevant Fungi Led to a <scp>d</scp>-Glucose Esterified Polyketide with a Terpene-like Core Structure
Natural Product Biosynthesis
Engineered Production of Strictosidine and Analogues in Yeast
Discovery and characterization of a terpene biosynthetic pathway featuring a norbornene-forming Diels-Alderase
Biosynthesis of Terpenoid–Pyrrolobenzoxazine Hybrid Natural Product CJ‐12662
Structural basis for the biosynthesis of lovastatin
Harzianic Acid from <i>Trichoderma afroharzianum</i> Is a Natural Product Inhibitor of Acetohydroxyacid Synthase
Prospecting for natural products by genome mining and microcrystal electron diffraction
Targeted Genome Mining Reveals the Biosynthetic Gene Clusters of Natural Product CYP51 Inhibitors
Cell-Free Total Biosynthesis of Plant Terpene Natural Products Using an Orthogonal Cofactor Regeneration System
High-Titer Production of Olivetolic Acid and Analogs in Engineered Fungal Host Using a Nonplant Biosynthetic Pathway
Recent developments in self-resistance gene directed natural product discovery
An enzymatic Alder-ene reaction
Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted <scp>l</scp> -Pipecolic Acids
Discovery and Biocatalytic Application of a PLP-Dependent Amino Acid γ-Substitution Enzyme That Catalyzes C–C Bond Formation
Iterative Catalysis in the Biosynthesis of Mitochondrial Complex II Inhibitors Harzianopyridone and Atpenin B
Fungal siderophore biosynthesis catalysed by an iterative nonribosomal peptide synthetase
Engineered mitochondrial production of monoterpenes in Saccharomyces cerevisiae
Enzyme-Catalyzed Inverse-Electron Demand Diels–Alder Reaction in the Biosynthesis of Antifungal Ilicicolin H
Genome-Mined Diels–Alderase Catalyzes Formation of the <i>cis</i>-Octahydrodecalins of Varicidin A and B
Uncovering Small Molecules that Mediate Plant-Fungi Interactions
Uncovering Small Molecules that Mediate Plant-Fungi Interactions
Discovery and Characterization of SAM-Dependent Pericyclases
Collaborative Research: SusChEM: A Robust Yeast Platform for the Synthesis and Engineering of Polyketide-Based Pharmaceuticals and Chemicals
Collaborative Research: Metabolite-responsive regulators for polyketide pathway engineering
Biosynthetic Engineering Approaches towards Generating New Tetracycline Antibiotics
PECASE: Bioengineering of Secondary Metabolic Pathways