Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Ubiquitin and proteasome pathways, Methane Hydrates and Related Phenomena, HIV Research and Treatment, and Cellular transport and secretion.
Structural basis of insulin receptor antagonism by bivalent site 1-site 2 ligands
Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase
Direct tests of cytochrome <i>c</i> and <i>c</i> <sub>1</sub> functions in the electron transport chain of malaria parasites
The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission
Symmetric and asymmetric receptor conformation continuum induced by a new insulin
Active conformation of the p97-p47 unfoldase complex
Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads
Peptoid Residues Make Diverse, Hyperstable Collagen Triple-Helices
Structure of the Cdc48 segregase in the act of unfolding an authentic substrate
Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation
Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases
Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4
Novel four-disulfide insulin analog with high aggregation stability and potency
Selective Kinase Inhibition Shows That Bur1 (Cdk9) Phosphorylates the Rpb1 Linker <i>In Vivo</i>
Vms1p is a release factor for the ribosome-associated quality control complex
Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase
The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets
A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription
Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism
Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria
FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs
Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase
Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines
Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs)
Design and characterization of ebolavirus <scp>GP</scp> prehairpin intermediate mimics as drug targets
Structural Biology of the Proteasome
Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler
The Oligomeric State of the Active Vps4 AAA ATPase
Structure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT
MRI Consortium: Acquisition of a Heterogeneous, Shared, Computing Instrument to Enable Science and Computing Research by the Mass. Green High Performance Computing Consortium
MRI Consortium: Acquisition of a Heterogeneous, Shared, Computing Instrument to Enable Science and Computing Research by the Mass. Green High Performance Computing Consortium
Collaborative Research: CI-TEAM Demo: Harnessing Cyberinfrastructure for K-12 STEM Education
"Collaborative Research: Petascale Artic, Atlantic and Antarctic Virtual Experiment"
Cloud-computing infrastructure and technology for education (C.I.T.E)
Collaborative Research: AOMIP: Synthesis and integration
Trends in Industrial Support of University-Based Cooperative Research