Area of research
Molecular Biology · Oncology
Research interest
Research interests include Epigenetics and DNA Methylation, Ubiquitin and proteasome pathways, Peptidase Inhibition and Analysis, and Advanced Proteomics Techniques and Applications.
Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver.
Multiplexed Photo-Cross-Linking Reveals Comprehensive Midnolin Interactome: Insights into Ubiquitin-Independent Degradation and Functional Diversity.
Multi-omics Analysis Reveals Comprehensive Aberrant Protein and Phosphorylation Characteristics in Breast Cancer and Paired Metastatic Lymph Nodes.
Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads
Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads.
CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity
Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer.
E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat.
Characterization of substrate distribution and functional implication of lysine acylations in Staphylococcus aureus
Visible-Light-Controlled Residue-Selective Cross-Linking for Deciphering Protein Complexes and Dynamic Protein-Protein Interactions in Live Cells
Integrative Dynamic Proteomics and Acyl-Proteomics Analyses in <i>Clostridium butyricum</i>.
Multi-omics analysis reveals RNA polymerase II degradation as a novel mechanism of PF-3758309's anti-tumor activity.
Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform.
Visible‐Light‐Controlled Lysine‐Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells
Integrative Proteomics and Histone PTMomics Study on Anti-TNBC Effect of JIB-04.
Multiomic Analysis of <i>Candida albicans</i> Adaptation during Commensal Coexistence with <i>Staphylococcus aureus</i>.
Phosphoproteomic and Acetylomic Characterization of Colorectal Cancer Cells Treated with Kinase Inhibitors.
Visible-Light-Controlled Lysine-Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells.
Characterization of the Biological Effect Mediated by Mycobacterial Kinase PknG on Protein Phosphorylation and Acetylation.
Dynamic Proteomic and PTMomic Characterization of Mycobacteria after Clinical Pharmaceutical Intervention.
Expanding the Chemistry of Acyl Diazo Electrophile as a Tunable Warhead for Covalent Targeting of KRAS (G12D) Mutant.
Multiomic Analysis of <i>Candida albicans</i> Adaptation during Commensal Coexistence with <i>Staphylococcus aureus</i>
DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding.
Substrate and Functional Diversity of Protein Lysine Post-translational Modifications
DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser<sup>56</sup> to diminish pancreatic β cell function upon overnutrition.
Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers.
Substrate and Functional Diversity of Protein Lysine Post-translational Modifications.
The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism.
Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response.
Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells.