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Florian Klein

Chirurgische Universitätsklinik Heidelberg · DE
Area of research
Infectious Diseases · Virology
Research interest
Research interests include HIV Research and Treatment, SARS-CoV-2 and COVID-19 Research, Immune Cell Function and Interaction, and COVID-19 Clinical Research Studies.
h-index
66
citations
21,359
works
389
NIH funding
primary concept
Medicine
email

Recent publications

Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332gp120 glycan-independent epitope
Nature Immunology 2026cited by 4position: lastdoi
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control
Nature Immunology 2026cited by 1position: middledoi
Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation
Nature 2025cited by 8position: middledoi
Hybrid immunity-based induction of durable pan-endemic-coronavirus immunity in the elderly
Cell Reports 2025cited by 4position: middledoi
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy
Nature Immunology 2025cited by 4position: lastdoi
ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer
Nature Communications 2025cited by 3position: middledoi
Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Cancer Immunology Research 2024cited by 13position: middledoi
Blocking the angiopoietin-2–dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis
JCI Insight 2024cited by 11position: middledoi
Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa
Cell 2023cited by 53position: middledoi
Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion
Nature Communications 2023cited by 35position: middledoi
Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning
Cell Host & Microbe 2023cited by 30position: middledoi
Dynamics and durability of HIV-1 neutralization are determined by viral replication
Nature Medicine 2023cited by 17position: lastdoi
Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity
Frontiers in Immunology 2023cited by 8position: middledoi
Short- and long-term T cell and antibody responses following dexamethasone treatment in COVID-19
JCI Insight 2023cited by 6position: middledoi
mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant
Nature Medicine 2022cited by 430position: lastdoi
SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns
Cell Host & Microbe 2022cited by 85position: lastdoi
Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial
The Lancet Microbe 2022cited by 80position: middledoi
Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization
Immunity 2022cited by 53position: lastdoi
Neutralisation sensitivity of the SARS-CoV-2 omicron BA.2.75 sublineage
The Lancet Infectious Diseases 2022cited by 33position: lastdoi
SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod
Journal of Neurology Neurosurgery & Psychiatry 2022cited by 31position: middledoi
A naturally arising broad and potent CD4-binding site antibody with low somatic mutation
Science Advances 2022cited by 24position: middledoi
Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study
The Lancet Respiratory Medicine 2021cited by 355position: middledoi
CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses
Cancer Immunology Research 2021cited by 94position: middledoi
Long-term immunogenicity of BNT162b2 vaccination in older people and younger health-care workers
The Lancet Respiratory Medicine 2021cited by 85position: middledoi
Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers
Cell Host & Microbe 2021cited by 61position: lastdoi
Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients
Cell 2020cited by 398position: lastdoi
Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody
Cell 2020cited by 153position: lastdoi
Innovations, challenges, and minimal information for standardization of humanized mice
EMBO Molecular Medicine 2020cited by 128position: middledoi
Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay
PLoS ONE 2020cited by 76position: middledoi
Hepatitis C reference viruses highlight potent antibody responses and diverse viral functional interactions with neutralising antibodies
Gut 2020cited by 31position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Michel C. Nussenzweig · Rockefeller University29 papers (2012–2022)Michael S. Seaman · Harvard University19 papers (2012–2022)Pamela J. Björkman · California Institute of Technology16 papers (2012–2022)Henning Gruell · Bernhard Nocht Institute for Tropical Medicine13 papers (2012–2022)Johannes F. Scheid · Broad Institute10 papers (2012–2022)Joshua A. Horwitz · Rockefeller University9 papers (2012–2015)Anthony P. West · California Institute of Technology9 papers (2013–2022)Lilian Nogueira · Rockefeller University8 papers (2014–2022)Kanika Vanshylla · Johnson & Johnson (Netherlands)8 papers (2020–2023)Hugo Mouquet · Institut Pasteur8 papers (2012–2014)Philipp Schommers · University of Cologne7 papers (2019–2023)Leif Erik Sander · Charité - Universitätsmedizin Berlin7 papers (2021–2025)Clara Lehmann · University of Würzburg7 papers (2012–2022)Marina Caskey · Rockefeller University6 papers (2015–2022)Ron Diskin · Weizmann Institute of Science6 papers (2012–2019)Christoph Kreer · Chirurgische Universitätsklinik Heidelberg6 papers (2019–2025)Gerd Fätkenheuer · Janssen (United States)6 papers (2012–2022)Anna Gazumyan · Rockefeller University6 papers (2014–2017)Julio C. C. Lorenzi · Rockefeller University6 papers (2014–2022)Bruce D. Walker · Active Technologies (Italy)5 papers (2012–2022)