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Joseph A. Piccirilli

University of Chicago · US
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Area of research
Molecular Biology
Research interest
Research interests include RNA and protein synthesis mechanisms, DNA and Nucleic Acid Chemistry, RNA modifications and cancer, and Advanced biosensing and bioanalysis techniques.
h-index
53
citations
9,553
works
255
NIH funding
primary concept
email

Recent publications

Genome-wide profiling of tRNA modifications by Induro-tRNAseq reveals coordinated changes
Nature Communications 2025cited by 19position: middledoi
Functional Relevance of <scp>CASP16</scp> Nucleic Acid Predictions as Evaluated by Structure Providers
Proteins Structure Function and Bioinformatics 2025cited by 11position: middledoi
Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 10position: middledoi
Mechanistic studies of small molecule ligands selective to RNA single G bulges
Nucleic Acids Research 2025cited by 2position: middledoi
RNA-Puzzles Round V: blind predictions of 23 RNA structures
Nature Methods 2024cited by 59position: middledoi
Unraveling RNA Conformation Dynamics in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episode Syndrome with Solid-State Nanopores
ACS Nano 2024cited by 18position: middledoi
A potential role for RNA aminoacylation prior to its role in peptide synthesis
Proceedings of the National Academy of Sciences 2024cited by 15position: middledoi
The Role of General Acid Catalysis in the Mechanism of an Alkyl Transferase Ribozyme
ACS Catalysis 2024cited by 14position: middledoi
Structural basis for promiscuity in ligand recognition by yjdF riboswitch
Cell Discovery 2024cited by 5position: lastdoi
Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly
Nature Methods 2022cited by 53position: middledoi
Structural Basis for Fluorescence Activation by Pepper RNA
ACS Chemical Biology 2022cited by 22position: lastdoi
The SARS-CoV-2 Programmed −1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography
ACS Chemical Biology 2021cited by 81position: lastdoi
The Varkud Satellite Ribozyme: A Thirty-Year Journey through Biochemistry, Crystallography, and Computation
Accounts of Chemical Research 2021cited by 13position: lastdoi
Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures
Nature Chemistry 2020cited by 80position: middledoi
Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme
Nature Chemistry 2020cited by 55position: middledoi
Hachimoji DNA and RNA: A genetic system with eight building blocks
Science 2019cited by 497position: middledoi
An Ontology for Facilitating Discussion of Catalytic Strategies of RNA-Cleaving Enzymes
ACS Chemical Biology 2019cited by 59position: middledoi
Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes
Journal of the American Chemical Society 2019cited by 57position: middledoi
The L-platform/L-scaffold framework: a blueprint for RNA-cleaving nucleic acid enzyme design
RNA 2019cited by 39position: middledoi
Evidence for a Catalytic Strategy to Promote Nucleophile Activation in Metal-Dependent RNA-Cleaving Ribozymes and 8-17 DNAzyme
ACS Catalysis 2019cited by 31position: middledoi
Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes.
PubMed 2019cited by 30position: middledoi
A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites
Nature Communications 2019cited by 28position: lastdoi
Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation
ACS Chemical Biology 2019cited by 25position: lastdoi
Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif
Nature Communications 2018cited by 49position: lastdoi
RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme
RNA 2017cited by 205position: middledoi
Synthesizing topological structures containing RNA
Nature Communications 2017cited by 37position: middledoi
Affinity maturation of a portable Fab–RNA module for chaperone-assisted RNA crystallography
Nucleic Acids Research 2017cited by 34position: lastdoi
Prolactin Receptor–Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity
Cancer Research 2017cited by 16position: lastdoi
Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers
The Journal of Immunology 2016cited by 101position: middledoi
Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen
Nucleic Acids Research 2016cited by 85position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Nan‐Sheng Li · Guilin University of Technology17 papers (2012–2025)Darrin M. York · Rutgers, The State University of New Jersey8 papers (2013–2024)Sandip A. Shelke · University of Chicago6 papers (2014–2019)Saurja DasGupta · University of Notre Dame6 papers (2015–2021)Yaming Shao · University of North Carolina at Chapel Hill6 papers (2015–2024)Deepak Koirala · University of Maryland, Baltimore County6 papers (2017–2022)Steven A. Benner · Indiana University – Purdue University Indianapolis5 papers (2015–2020)Qing Dai · Howard Hughes Medical Institute5 papers (2012–2019)Anna Lewicka · University of Illinois Chicago5 papers (2019–2025)David M.J. Lilley · Xiamen University5 papers (2012–2024)Michael E. Harris · University of Florida4 papers (2013–2019)Phoebe A. Rice · University of Chicago4 papers (2013–2019)Shuichi Hoshika · Indiana University – Purdue University Indianapolis4 papers (2015–2020)Timothy J. Wilson · University of Dundee4 papers (2012–2024)Hao Huang · Zhengzhou University3 papers (2014–2019)Benjamin P. Weissman · University of Chicago3 papers (2018–2020)Yelena Koldobskaya · California Institute of Technology3 papers (2014–2019)Di Liu · Army Medical University3 papers (2017–2022)James R. Fuller · University of Chicago3 papers (2015–2019)Abir Ganguly · Pennsylvania State University3 papers (2019–2020)
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