Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include PI3K/AKT/mTOR signaling in cancer, Protein Kinase Regulation and GTPase Signaling, Cellular transport and secretion, and Chronic Lymphocytic Leukemia Research.
DET1 dynamics underlie cooperative ubiquitination by CRL4 <sup>DET1-COP1</sup> complexes
Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
CERT1 mutations perturb human development by disrupting sphingolipid homeostasis
Accurate prediction of protein structures and interactions using a three-track neural network
Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors
Crystal structure of an archaeal CorB magnesium transporter
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Characterization of the c10orf76‐PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication
Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange
Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States
Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention
Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ
Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11
Collaborative Research: RESEARCH-PGR: Comparative genomics of the capitulum: deciphering the molecular basis of a key floral innovation
Evolutionary Genomics of Abiotic Stress Resistance in Wild and Cultivated Sunflowers
DISSERTATION RESEARCH: Comparative genomic analysis of the Compositae, focusing on Carthamus tinctorius L. (safflower)
YIA: Identifying the Targets of Selection During Sunflower Domestication
YIA: Identifying the Targets of Selection During Sunflower Domestication
Japan JSPS Program: Influence of Thyroid Hormones on the Behavior of Larval Flounder
Site-specific Mutagenesis of Sequences Implicated in Auto- catalytic Processing of Intron Within Tetrahymena 26S Ribo- somal RNA Precursor
1978 National Needs Postdoctoral Fellowship Program