Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include RNA Research and Splicing, RNA and protein synthesis mechanisms, MicroRNA in disease regulation, and RNA modifications and cancer.
The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation
Global stabilization of the transcriptome in mitotic cells
Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders
The G3BP stress-granule proteins reinforce the integrated stress response translation programme
Functional microRNA targeting without seed pairing
PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility
Derepression of a single microRNA target causes female infertility in mice
5′ untranslated regions tune <i>Toxoplasma</i> translation
Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos
Nuclear release of eIF1 restricts start-codon selection during mitosis
The structural basis for RNA slicing by human Argonaute2
The guide-RNA sequence dictates the slicing kinetics and conformational dynamics of the Argonaute silencing complex
Widespread destabilization of <i>Caenorhabditis elegans</i> microRNAs by the E3 ubiquitin ligase EBAX-1
A statistical approach for identifying primary substrates of ZSWIM8-mediated microRNA degradation in small-RNA sequencing data
The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position
Endogenous transcripts direct microRNA degradation in Drosophila, and this targeted degradation is required for proper embryonic development
The interplay between translational efficiency, poly(A) tails, microRNAs, and neuronal activation
The molecular basis of coupling between poly(A)-tail length and translational efficiency
Degradation of host translational machinery drives tRNA acquisition in viruses
Ago2 protects <i>Drosophila</i> siRNAs and microRNAs from target-directed degradation, even in the absence of 2′-<i>O</i>-methylation
The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation
The Dynamics of Cytoplasmic mRNA Metabolism
The biochemical basis for the cooperative action of microRNAs
MicroRNA Clustering Assists Processing of Suboptimal MicroRNA Hairpins through the Action of the ERH Protein
MicroRNAs Cause Accelerated Decay of Short-Tailed Target mRNAs
Xrn1p acts at multiple steps in the budding-yeast RNAi pathway to enhance the efficiency of silencing
The biochemical basis of microRNA targeting efficacy
Excised linear introns regulate growth in yeast
m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis