Area of research
Oncology · Computational Theory and Mathematics
Research interest
Research focused on Mutant and Computational biology, with related work in Thermolabile, Small molecule, Ligand (biochemistry). Notable publications include '2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells', 'Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines', and 'A Structure-Guided Molecular Chaperone Approach for Restoring the Transcriptional Activity of the p53 Cancer Mutant Y220C'.
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and SARS-CoV-2 variants
Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm
A Structure-Guided Molecular Chaperone Approach for Restoring the Transcriptional Activity of the p53 Cancer Mutant Y220C
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines
A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway
2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells
Harnessing Fluorine–Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs