Area of research
Hepatology · Molecular Biology
Research interest
Research focused on Cancer and Hepatocellular carcinoma, with related work in Transcriptome, Cancer research, IDH2. Notable publications include 'Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas', 'Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer', and 'Functional and genetic deconstruction of the cellular origin in liver cancer'.
miR‐579‐3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3‐Kinase–Protein Kinase B Pathway in Chronically Inflamed Liver
Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes‐Associated Protein 1 Activation and Transient Expansion of Stem‐Like Cancer Cells
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis
Application of patient‐derived liver cancer cells for phenotypic characterization and therapeutic target identification
Adverse genomic alterations and stemness features are induced by field cancerization in the microenvironment of hepatocellular carcinomas
Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice
Transcriptional Induction of Periostin by a Sulfatase 2–TGFβ1–SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma
DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration
Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype
Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress
Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer
Functional and genetic deconstruction of the cellular origin in liver cancer
Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM+ AFP+ hepatocellular carcinoma
Genomic Predictors for Recurrence Patterns of Hepatocellular Carcinoma: Model Derivation and Validation
SnapShot: Hepatocellular Carcinoma
Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis
Sirtuin-6–Dependent Genetic And Epigenetic Alterations Are Associated With Poor Clinical Outcome in Hepatocellular Carcinoma Patients
Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits
CellMiner<scp>HCC</scp>: a microarray‐based expression database for hepatocellular carcinoma cell lines
Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas
Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma
mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma
Loss of c-Met accelerates development of liver fibrosis in response to CCl4 exposure through deregulation of multiple molecular pathways
Thyroid Regeneration: Characterization of Clear Cells After Partial Thyroidectomy
Genetic signatures shared in embryonic liver development and liver cancer define prognostically relevant subgroups in HCC