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Xiaowei Zhuang

Harvard University · US
Area of research
Molecular Biology · Biophysics
Research interest
Research interests include Advanced Fluorescence Microscopy Techniques, Single-cell and spatial transcriptomics, RNA and protein synthesis mechanisms, and Cell Image Analysis Techniques.
h-index
117
citations
65,682
works
350
NIH funding
primary concept
Chemistry
email

Recent publications

Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis
bioRxiv (Cold Spring Harbor Laboratory) 2026cited by 1position: middledoi
Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue
Cell 2025cited by 34position: lastdoi
High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer
Science 2025cited by 18position: middledoi
Cell type–specific 3D-genome organization and transcription regulation in the brain
Science Advances 2025cited by 15position: lastdoi
The membrane skeleton is constitutively remodeled in neurons by calcium signaling
Science 2025cited by 6position: lastdoi
Author Correction: A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
Nature Medicine 2025cited by 0position: middledoi
A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
Nature Medicine 2024cited by 70position: middledoi
The commitment of the human cell atlas to humanity
Nature Communications 2024cited by 18position: lastdoi
A platform for multimodal <i>in vivo</i> pooled genetic screens reveals regulators of liver function
bioRxiv (Cold Spring Harbor Laboratory) 2024cited by 9position: lastdoi
Three-dimensional single-cell transcriptome imaging of thick tissues
eLife 2024cited by 3position: lastdoi
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Nature 2023cited by 1,000position: middledoi
Molecularly defined and spatially resolved cell atlas of the whole mouse brain
Nature 2023cited by 456position: lastdoi
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 138position: middledoi
A molecularly defined and spatially resolved cell atlas of the whole mouse brain
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 69position: lastdoi
Three-dimensional single-cell transcriptome imaging of thick tissues
eLife 2023cited by 42position: lastdoi
Inference of single cell profiles from histology stains with the Single Cell omics from Histology Analysis Framework (SCHAF)
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 36position: middledoi
Three-dimensional single-cell transcriptome imaging of thick tissues
2023cited by 5position: lastdoi
High-content CRISPR screening
Nature Reviews Methods Primers 2022cited by 564position: lastdoi
Molecular and spatial signatures of mouse brain aging at single-cell resolution
Cell 2022cited by 402position: lastdoi
Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH
Science 2022cited by 282position: lastdoi
High-content CRISPR screening
Nature Reviews Methods Primers 2022cited by 251position: lastdoi
Spatially resolved epigenomic profiling of single cells in complex tissues
Cell 2022cited by 184position: lastdoi
A preoptic neuronal population controls fever and appetite during sickness
Nature 2022cited by 174position: middledoi
Proteomic and functional analyses of the periodic membrane skeleton in neurons
Nature Communications 2022cited by 61position: lastdoi
Abstract PD6-03: Spatio-molecular dissection of the breast cancer metastatic microenvironment
Cancer Research 2022cited by 1position: middledoi
Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram
Nature Methods 2021cited by 863position: middledoi
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
Cancer Cell 2021cited by 577position: middledoi
A multimodal cell census and atlas of the mammalian primary motor cortex
Nature 2021cited by 564position: middledoi
Spatially resolved cell atlas of the mouse primary motor cortex by MERFISH
Nature 2021cited by 525position: lastdoi
Spatially resolved single-cell genomics and transcriptomics by imaging
Nature Methods 2021cited by 254position: firstdoi

Grants

2008 Single Molecule Approaches to Biology, to be held at Colby-Sawyer College, New London, New Hampshire, August 17-22, 2008.
NSF0754429$10,0002008–2009PIRePORTER
CAREER: Single-molecule Studies of RNA and Ribonucleoprotein Enzymes
NSF0238773$503,1812003–2008PIRePORTER

Frequent collaborators

Jeffrey R. Moffitt · Boston Children's Hospital13 papers (2014–2019)Hazen P. Babcock · Harvard University12 papers (2012–2019)Catherine Dulac · Harvard University9 papers (2016–2025)Chenglong Xia · Innovative Genomics Institute9 papers (2012–2022)Meng Zhang · Scripps Research Institute8 papers (2020–2023)Ruobo Zhou · Pennsylvania State University8 papers (2014–2022)Siyuan Wang · Ningbo University7 papers (2014–2020)Jiang He · Howard Hughes Medical Institute7 papers (2012–2021)Sebastian Deindl · Uppsala University7 papers (2012–2019)Junjie Hao · Shanghai University7 papers (2016–2021)Stephen W. Eichhorn · Harvard University7 papers (2018–2023)Alistair N. Boettiger · Stanford University7 papers (2015–2018)Bogdan Bintu · Jacobs (United States)6 papers (2016–2021)Jonathan S. Weissman · Howard Hughes Medical Institute6 papers (2022–2026)Doory Kim · Hanyang University6 papers (2013–2018)Aaron R. Halpern · Harvard University Press6 papers (2022–2024)Guisheng Zhong · ShanghaiTech University6 papers (2012–2019)Rongxin Fang · Harvard University5 papers (2021–2024)Jun-Han Su · Harvard University Press5 papers (2016–2020)Tian Lu · Zhejiang University5 papers (2016–2022)