Area of research
Cancer Research · Oncology
Research interest
Xose S. Puente is Professor and Head of the Department of Biochemistry and Molecular Biology at the University of Oviedo. D. in 1998, he did a postdoc at The Scripps Research Institute (USA) on the role of proteases in cancer. Since 2003 he has been developing a line of research in comparative genomics and bioinformatics, participating in large international sequencing consortia. He has contributed to the development of tools for detecting tumour mutations, revolutionising our knowledge of chronic lymphocytic leukaemia by identifying more than 60 genes that are drivers of this pathology. Some of these mutations affect non-protein coding regions of great functional relevance, such as the NOTCH1 gene or the U1 snRNA.
Exercise and the hallmarks of cardiovascular aging
The aging modulator miR-29 is essential for adult cardiomyocyte function
From geroscience to precision geromedicine: Understanding and managing aging
Acyl-CoA-binding protein as a driver of pathological aging
Acyl-CoA-binding protein as a driver of pathological aging
Hallmarks of aging: Integrating molecular and social determinants
The vocabulary of geromedicine: gerovocabulary
Combined loss of ATG4B, ATG4C and ATG4D impairs systemic autophagy and triggers accelerated aging in mice
miR-29 is an important driver of aging-related phenotypes
miR-29 is an important driver of aging-related phenotypes.
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues.
Noncoding RNA Contribution to Aging and Lifespan.
miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses
Hallmarks of aging: An expanding universe
Meta-hallmarks of aging and cancer
Personalized Precision Medicine for Health Care Professionals: Development of a Competency Framework.
Analysis of ATG4C function <i>in vivo</i>.
Correction: Personalized Precision Medicine for Health Care Professionals: Development of a Competency Framework.
Correction: #43656 “Personalized Precision Medicine for Health Care Professionals: Development of a Competency Framework" Addendum to Acknowledgements and References corrections. (Preprint)
Correction: Personalized Precision Medicine for Health Care Professionals: Development of a Competency Framework (Preprint)
Exercise sustains the hallmarks of health
OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy
OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy.
Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells.
Personalized Precision Medicine for Health Care Professionals: Development of a Competency Framework (Preprint)
Autophagy in major human diseases
Autophagy in major human diseases
Old Paradoxes and New Opportunities for Appetite Control in Obesity.
ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration.