Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Ubiquitin and proteasome pathways, RNA modifications and cancer, RNA and protein synthesis mechanisms, and RNA Research and Splicing.
Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress
RNF10 and RIOK3 facilitate 40S ribosomal subunit degradation upon 60S biogenesis disruption or amino acid starvation
ExoSloNano: multimodal nanogold labels for identification of macromolecules in live cells and cryo-electron tomograms
Ubiquitin-dependent translation control mechanisms: Degradation and beyond
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis
HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses
Targeted protein degradation: from small molecules to complex organelles—a Keystone Symposia report
iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation
Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition
Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress
EDF1 coordinates cellular responses to ribosome collisions
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2
Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized
Bombardier Enables Delivery of Short-Form Bomanins in the Drosophila Toll Response
A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in <i>Caenorhabditis elegans</i>
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules
Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins
ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation
Site-specific identification and quantitation of endogenous SUMO modifications under native conditions
Identification of microsporidia host-exposed proteins reveals a repertoire of rapidly evolving proteins
Biallelic mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing
In vivo mapping of tissue- and subcellular-specific proteomes in <i>Caenorhabditis elegans</i>
Proteome complexity and the forces that drive proteome imbalance
Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements
The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins
The SCAR/WAVE complex polarizes PAN receptors and promotes division asymmetry in maize
Protecting the proteome: Eukaryotic cotranslational quality control pathways
Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex
SBIR Phase I: Novel advanced manufacturing technique for artificial blood vessels
Collaborative Research: Data-driven integration of biological with in-silico experiments to determine mechanistic effects of N-glycosylation on cellular electromechanical functions
Regulated sialylation modulates cardiac excitability and conduction
Regulated sialylation modulates cardiac excitability and conduction
Sodium Channel Differential Sialylation Throughout Development