Area of research
Molecular Biology · Immunology
Research interest
Research focused on Gene expression and Gene regulatory network, with related work in Cell biology, Computational biology, Systems biology. Notable publications include 'Model-Based Assessment of the Role of Uneven Partitioning of Molecular Content on Heterogeneity and Regulation of Differentiation in CD8 T-Cell Immune Responses', 'Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process', and 'SINCERITIES: inferring gene regulatory networks from time-stamped single cell transcriptional expression profiles'.
Modeling relaxation experiments with a mechanistic model of gene expression
One model fits all: Combining inference and simulation of gene regulatory networks
Hematopoietic differentiation is characterized by a transient peak of entropy at a single-cell level
Evidence for close molecular proximity between reverting and undifferentiated cells
Entropy as a measure of variability and stemness in single-cell transcriptomics
Reduction of a stochastic model of gene expression: Lagrangian dynamics gives access to basins of attraction as cell types and metastabilty
The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission
Model-Based Assessment of the Role of Uneven Partitioning of Molecular Content on Heterogeneity and Regulation of Differentiation in CD8 T-Cell Immune Responses
WASABI: a dynamic iterative framework for gene regulatory network inference
Erythroid differentiation displays a peak of energy consumption concomitant with glycolytic metabolism rearrangements
Drugs modulating stochastic gene expression affect the erythroid differentiation process
SINCERITIES: inferring gene regulatory networks from time-stamped single cell transcriptional expression profiles
Inferring gene regulatory networks from single-cell data: a mechanistic approach
Integrated time-lapse and single-cell transcription studies highlight the variable and dynamic nature of human hematopoietic cell fate commitment
Identification of Nascent Memory CD8 T Cells and Modeling of Their Ontogeny
Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process
IL-2 sensitivity and exogenous IL-2 concentration gradient tune the productive contact duration of CD8+ T cell-APC: a multiscale modeling study
Stochastic Fluctuations and Distributed Control of Gene Expression Impact Cellular Memory
The role of spatial organization of cells in erythropoiesis
Multiscale Modeling of the Early CD8 T-Cell Immune Response in Lymph Nodes: An Integrative Study
Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts
Finding Collections of k-Clique Percolated Components in Attributed Graphs