Area of research
Genetics · Pathology and Forensic Medicine
Research interest
Research interests include Chronic Lymphocytic Leukemia Research, Lymphoma Diagnosis and Treatment, Glycosylation and Glycoproteins Research, and Immunodeficiency and Autoimmune Disorders.
NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL
T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia
Acquired <i>BTK</i> mutations associated with resistance to noncovalent BTK inhibitors
Richter transformation: epigenetics to blame?
IGLV3-21 R110 Is a Prognostic Marker for Early Stage CLL Patients Under Ibrutinib Treatment or Watch & Wait: Results from the Double-Blind, Randomized, Placebo-Controlled GCLLSG CLL12 Trial
Secondary resistance to idelalisib is characterized by upregulation of IGF1R rather than by MAPK/ERK pathway mutations
Genetic Markers and Front Line FCR/BR Vs. Rve, Gve and Give Treatment - Outcome Results from the CLL13/GAIA Trial
Clonal evolution in chronic lymphocytic leukemia is scant in relapsed but accelerated in refractory cases after chemo(immune) therapy
DNA methylation of chronic lymphocytic leukemia with differential response to chemotherapy
From Biology to Therapy: The CLL Success Story
Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL
FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL
Control of chronic lymphocytic leukemia development by clonally-expanded CD8+ T-cells that undergo functional exhaustion in secondary lymphoid tissues
NOTCH1 Signaling Is Activated in CLL By Mutations of FBXW7 and Low Expression of USP28 at 11q23
Microenvironmental Stromal Cells Rescue CLL Cells from Apoptosis Via Hypoxia That Can be Targeted Therapeutically
Antineoplastic potential of curcumin (cooperative study in Bulgaria and Germany)
Corrigendum to “Alkylphosphocholines and curcumin induce programmed cell death in cutaneous T-cell lymphoma cell lines” [Leukemia Res. 38 (2014) 49–56]
Alkylphosphocholines and curcumin induce programmed cell death in cutaneous T-cell lymphoma cell lines
Interleukin-6, osteopontin and Raf/MEK/ERK signaling modulate the sensitivity of human myeloma cells to alkylphosphocholines
A particular expression pattern of CD13 epitope 7H5 in chronic lymphocytic leukaemia – a possible new therapeutic target