← back to search

Alexander R. Horswill

VA Eastern Colorado Health Care System · US
Area of research
Molecular Biology · Infectious Diseases
Research interest
Research interests include Antimicrobial Resistance in Staphylococcus, Bacterial biofilms and quorum sensing, Biochemical and Structural Characterization, and Antimicrobial Peptides and Activities.
h-index
82
citations
26,048
works
274
NIH funding
primary concept
email

Recent publications

Staphylococcus aureus: The Bug Behind the Itch in Atopic Dermatitis
Journal of Investigative Dermatology 2024cited by 23position: lastdoi
S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis
Cell 2023cited by 131position: middledoi
Staphylococcus epidermidis activates keratinocyte cytokine expression and promotes skin inflammation through the production of phenol-soluble modulins
Cell Reports 2023cited by 40position: middledoi
The impact of nutritional immunity on Group B streptococcal pathogenesis during wound infection
mBio 2023cited by 14position: middledoi
Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model
Cell Reports 2023cited by 13position: lastdoi
The Ubiquitous Human Skin Commensal Staphylococcus hominis Protects against Opportunistic Pathogens
mBio 2022cited by 108position: lastdoi
The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia
Cell Reports 2022cited by 41position: middledoi
Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis
Journal of Allergy and Clinical Immunology 2020cited by 183position: middledoi
Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome
Cell Reports 2020cited by 124position: middledoi
Short chain fatty acids produced by Cutibacterium acnes inhibit biofilm formation by Staphylococcus epidermidis
Scientific Reports 2020cited by 97position: middledoi
Triterpenoid acids isolated from Schinus terebinthifolia fruits reduce Staphylococcus aureus virulence and abate dermonecrosis
Scientific Reports 2020cited by 27position: middledoi
Regulation of <i>Staphylococcus aureus</i> Virulence
Microbiology Spectrum 2019cited by 536position: lastdoi
Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis
Science Translational Medicine 2019cited by 281position: middledoi
Identification of Extracellular DNA-Binding Proteins in the Biofilm Matrix
mBio 2019cited by 194position: lastdoi
Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice
Frontiers in Microbiology 2019cited by 83position: middledoi
Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice
Frontiers in Microbiology 2019cited by 55position: middledoi
Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models
Scientific Reports 2017cited by 70position: middledoi
Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin
mBio 2015cited by 182position: middledoi
Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance
PLoS ONE 2015cited by 112position: lastdoi
<scp>R</scp>ot is a key regulator of <scp><i>S</i></scp><i>taphylococcus aureus</i> biofilm formation
Molecular Microbiology 2015cited by 81position: lastdoi
pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37
Proceedings of the National Academy of Sciences 2014cited by 205position: middledoi
Flipping the switch: tools for detecting small molecule inhibitors of staphylococcal virulence
Frontiers in Microbiology 2014cited by 44position: lastdoi
Bacteria activate sensory neurons that modulate pain and inflammation
Nature 2013cited by 926position: middledoi
Reduced Vancomycin Susceptibility in an<i>In Vitro</i>Catheter-Related Biofilm Model Correlates with Poor Therapeutic Outcomes in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus
Antimicrobial Agents and Chemotherapy 2013cited by 63position: middledoi
The Role of Innate Immunity in Promoting SaeR/S-Mediated Virulence in Staphylococcus aureus
Journal of Innate Immunity 2013cited by 51position: middledoi
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
Natural Product Reports 2012cited by 2,074position: middledoi
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung
Nature 2012cited by 803position: middledoi
Low Levels of β-Lactam Antibiotics Induce Extracellular DNA Release and Biofilm Formation in Staphylococcus aureus
mBio 2012cited by 286position: lastdoi
Alpha-Toxin Induces Programmed Cell Death of Human T cells, B cells, and Monocytes during USA300 Infection
PLoS ONE 2012cited by 115position: middledoi
Staphylococcus aureus Staphopain A inhibits CXCR2‐dependent neutrophil activation and chemotaxis
The EMBO Journal 2012cited by 107position: middledoi

Grants

Conference: 2023 Staphylococcal Diseases GRC and GRS: New Insights into Staphylococcal Biology, Disease Mechanisms and Treatment
NSF2334757$7,0002023–2023PIRePORTER

Frequent collaborators

Richard L. Gallo · University of San Diego7 papers (2019–2023)Michael R. Williams · University of California San Diego6 papers (2019–2023)Victor J. Torres · New York University5 papers (2012–2022)Cassandra L. Quave · Emory University4 papers (2014–2020)Heidi A. Crosby · University of Colorado Denver4 papers (2015–2019)J.S. Kavanaugh · University of Colorado Denver4 papers (2015–2022)Teruaki Nakatsuji · Universidad Católica Santo Domingo3 papers (2019–2020) · 3 papers (2012–2019)Lívia S. Zaramela · Universidade de Ribeirão Preto3 papers (2019–2022)Shadi Khalil · New York University3 papers (2019–2023) · 3 papers (2019–2023)James T. Lyles · Emory University3 papers (2015–2020)Laura Cau · Centre National de la Recherche Scientifique3 papers (2020–2020)Karsten Zengler · Scripps Institution of Oceanography3 papers (2019–2022)Cheryl L. Malone · University of Iowa3 papers (2012–2012)Christian Jenul · University of Leicester2 papers (2019–2019)Kate Nelson · The University of Texas MD Anderson Cancer Center2 papers (2015–2017)Arun Prakash · San Francisco General Hospital2 papers (2019–2019)Morgan M. Severn · University of Colorado Denver2 papers (2022–2023) · 2 papers (2015–2015)