Ruimiao Chang

Area of research

Spectroscopy · Analytical Chemistry

Research interest

Research topics from publications: Protective Role of Deoxyschizandrin and Schisantherin A against Myocardial Ischemia–Reperfusion Injury in Rats; Separation and determination of corynoxine and corynoxine B using chiral ionic liquid and hydroxypropyl‐β‐cyclodextrin as additives by field‐amplified sample stacking in capillary electrophoresis; Quality evaluation of Guan‐Xin‐Ning injection based on fingerprint analysis and simultaneous separation and determination of seven bioactive constituents by capillary electrophoresis; Crystallization and relaxation dynamics of amorphous loratadine under different quench-cooling temperatures; Application of thermal alkaline hydrolysis technology to improve the loading and in-vitro release of gallic acid in UiO-66; Modifying of magnetic UiO-66-NH2 as a new nanosorbent by thermo-alkali-hydrolysis technology for highly efficient enrichment and determination of quercetin in apple peel; Simultaneous separation and determination of seven isoflavones in Radix Puerariae by capillary electrophoresis with a dual cyclodextrin system; Cardiac Muscle/Cell Membrane Chromatography-Offline-Liquid Chromatography/Mass Spectrometry Method to Identify Bioactive Components from Traditional Chinese Medicines; Simultaneous separation and determination of hirsutine and hirsuteine by cyclodextrin‐modified micellar electrokinetic capillary chromatography; Separation and simultaneous determination of seven bioactive components in Tripterygium wilfordii Hook. F. and Tripterygium preparations by micellar electrokinetic capillary chromatography. Representative work: BACKGROUND: Our previous studies suggested that deoxyschizandrin (DSD) and schisantherin A (STA) may have cardioprotective effects, but information in this regard is lacking. Therefore, we explored the protective role of DSD and STA in myocardial ischemia-reperfusion (I/R) injury. METHODOLOGY/PRINCIPAL FINDINGS: Anesthetized male rats were treated once with DSD and STA (each 40 µmol/kg) through the tail vein after 45 min of ischemia, followed by 2-h reperfusion. Cardiac function, infarct size, biochemical markers, histopathology and apoptosis were measured and mRNA expression of gp91 (phox) in myocardial tissue assessed by RT-PCR. Neonatal rat cardiomyocytes were pretreated with DSD and STA Abstract A sensitive, fast, and effective method, field‐amplified sample stacking (FASS) in capilla

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