Area of research
Molecular Medicine · Genetics
Research interest
Research interests include Antibiotic Resistance in Bacteria, Bacterial Genetics and Biotechnology, Bacterial biofilms and quorum sensing, and Microbial Natural Products and Biosynthesis.
Energy expenditure and cellular activity underlie antibiotic tolerance of <i>Pseudomonas aeruginosa</i>.
A deformylase inhibitor expands therapeutic options for Lyme disease
A sulfur-containing nucleoside antibiotic from <i>Photorhabdus</i>.
The dynamic lateral gate of the mitochondrial β-barrel biogenesis machinery is blocked by darobactin A.
Small molecule produced by <i>Photorhabdus</i> interferes with ubiquinone biosynthesis in Gram-negative bacteria.
A Resistance-Evading Antibiotic for Treating Anthrax
An antibiotic from an uncultured bacterium binds to an immutable target
Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A
Teixobactin kills bacteria by a two-pronged attack on the cell envelope
Computational identification of a systemic antibiotic for Gram-negative bacteria
Computational identification of a systemic antibiotic for gram-negative bacteria.
A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections
The Role of Integration Host Factor in Escherichia coli Persister Formation.
A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections.
Recent Progress in Lyme Disease and Remaining Challenges
Bacterial persisters are a stochastically formed subpopulation of low-energy cells.
A selective antibiotic for Lyme disease
Predicting antimicrobial mechanism-of-action from transcriptomes: A generalizable explainable artificial intelligence approach.
Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis.
A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients.
Definitions and guidelines for research on antibiotic persistence
A new antibiotic selectively kills Gram-negative pathogens
Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells.
Genetic Basis of Persister Tolerance to Aminoglycosides in Escherichia coli
Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2
On the Mechanism of Berberine–INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials*
A problem of persistence: still more questions than answers?
Collaborative Research: D3SC: CDS&E: Predictive Discovery of Porphyrin Molecules and their Response Properties using Smart Objects-Enabled Machine Learning
CAREER: From Self-Assembled Monolayers to Molecular Multilayers: The Electronic Properties of Molecular Junctions
BRIGE: The Design and Characterization of a Multifunctional Chemiresistor Sensor Array
SGER: Apoptosis in Bacteria
Low Energy Shock in E. coli
Low Energy Shock in E. coli
"Low Energy Shock in E. coli"
The Mechanism of Energy Level Sensing in Escherichia coli