Area of research
Epidemiology · Physiology
Research interest
Research interests include Autophagy in Disease and Therapy, Calcium signaling and nucleotide metabolism, Telomeres, Telomerase, and Senescence, and Cellular transport and secretion.
Galactomyces ferment filtrate upregulates anchoring junctions and stabilizes actin to maintain the Young's modulus of skin cells in vitro.
Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.
AMPK senses cellular levels of nicotinamide adenine dinucleotide
Expanded Evaluation of a Commercial Immunofluorescence Kit for Detecting Microsporidia In Vitro
Microsporidian obligate intracellular parasites subvert autophagy of infected mammalian cells to promote their own growth.
Activation of pro-survival autophagy by a small molecule promoting p62 oligomerisation
Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.
Mitochondrial sodium/calcium exchanger (NCLX) regulates basal and starvation-induced autophagy through calcium signaling.
Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models.
Apoptotic stress causes mtDNA release during senescence and drives the SASP
The autophagy-NAD axis in longevity and disease.
NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy.
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science
Metabolic function of autophagy is essential for cell survival.
The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress
Oncogenic
<i>PIK3CA</i>
corrupts growth factor signaling specificity
Mitochondrial Sodium/Calcium Exchanger (NCLX) Regulates Basal and Starvation-Induced Autophagy Through Calcium Signaling
The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress
Autophagy promotes cell survival by maintaining NAD levels
NDP52 acts as a redox sensor in PINK1/Parkin‐mediated mitophagy
Autophagy promotes cell survival by maintaining NAD levels.
Microsporidian obligate intracellular parasites subvert autophagy of infected mammalian host cells to promote their own growth
Cx43 promotes exocytosis of damaged lysosomes through actin remodelling
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
mTORC1 activity is supported by spatial association with focal adhesions
mTORC1 activity is supported by spatial association with focal adhesions
Ochratoxin A induces NLRP3 inflammasome-mediated pyroptosis via activation of ROS modulated by autophagy in vitro
Autophagy promotes cell survival by maintaining NAD(H) levels
Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function.