Area of research
Health, Toxicology and Mutagenesis · Epidemiology
Research interest
Chronic lymphocytic leukemia (CLL) can arise from lymphoid clonal hematopoiesis of indeterminate potential (L-CHIP), but many individuals who develop CLL lack detectable L-CHIP prior to diagnosis. To identify additional predictors of CLL risk, we analyze mitochondrial heteroplasmy in 419,154 individuals from the UK Biobank (UKB). Heteroplasmy is associated with a 1.5-fold increased risk of developing CLL, and this risk rises to 4-fold when accounting for deleterious heteroplasmic variants. These findings are confirmed in an independent cohort, the All of Us Research Program (AoU). Notably, the associations remain significant even in the absence of L-CHIP, highlighting heteroplasmy's potential utility as an independent biomarker.
Reporting guideline for Chatbot Health Advice studies: the CHART statement
Deleterious mitochondrial heteroplasmies exhibit increased longitudinal change in variant allele fraction
Intracranial Atherosclerotic Disease and Incident Dementia: The ARIC Study (Atherosclerosis Risk in Communities)
Effect of Isocaloric, Time-Restricted Eating on Body Weight in Adults With Obesity
A Metabolomics Approach to Identify Metabolites Associated With Mortality in Patients Receiving Maintenance Hemodialysis
Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality
Multivariate longitudinal data for survival analysis of cardiovascular event prediction in young adults: insights from a comparative explainable study
Circulating bile acid concentrations and non‐alcoholic fatty liver disease in Guatemala
A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies
Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease
Evaluation of mitochondrial DNA copy number estimation techniques
Chronic obstructive pulmonary disease and lung cancer incidence in never smokers: a cohort study
Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs
Sex Hormones and Incident Heart Failure in Men and Postmenopausal Women: The Atherosclerosis Risk in Communities Study
Mitochondrial DNA copy number and incident atrial fibrillation
Associations between <i>Helicobacter pylori</i> with nonalcoholic fatty liver disease and other metabolic conditions in Guatemala
Coffee and Tea Consumption in the Early Adult Lifespan and Left Ventricular Function in Middle Age: The CARDIA Study
Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality
Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes
Racial Differences in Sudden Cardiac Death
Resting Heart Rate, Short-Term Heart Rate Variability and Incident Atrial Fibrillation (from the Multi-Ethnic Study of Atherosclerosis (MESA))
Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
Endogenous Sex Hormones and Incident Cardiovascular Disease in Post-Menopausal Women
Adiposity and Incident Heart Failure and its Subtypes
Effect of long-term selenium supplementation on mortality: Results from a multiple-dose, randomised controlled trial
Incidence of Diabetes After Cancer Development
A dose-response meta-analysis of chronic arsenic exposure and incident cardiovascular disease
Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease
Serum uric acid levels are associated with cardiovascular risk score: A post hoc analysis of the EURIKA study
Relation of Elevated Resting Heart Rate in Mid-Life to Cognitive Decline Over 20 Years (from the Atherosclerosis Risk in Communities [ARIC] Study)