Area of research
Endocrine and Autonomic Systems · Genetics
Research interest
Research interests include Neuroscience of respiration and sleep, High Altitude and Hypoxia, Ion channel regulation and function, and Neuroscience and Neuropharmacology Research.
A Hundred Years of the Chemosensory Synapse: A Tribute to Fernando de Castro.
Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer’s disease progression
Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer's disease progression.
Phosphodiesterase Inhibition Increases Striatal GDNF and Protects Against Preclinical Parkinsonism.
The carotid body oxygen sensor.
Acute oxygen sensing by arterial chemoreceptors with a mutant mitochondrial complex I ND6 subunit lacking reverse electron transport.
Intracellular signalling in arterial chemoreceptors during acute hypoxia and glucose deprivation: role of ATP.
Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality.
Hif1α-dependent mitochondrial acute O<sub>2</sub> sensing and signaling to myocyte Ca<sup>2+</sup> channels mediate arterial hypoxic vasodilation.
The PHD3-FOXO3 axis modulates the interferon type I response in microglia aggravating Alzheimer’s disease progression
Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice.
Rearrangement of cell types in the rat carotid body neurogenic niche induced by chronic intermittent hypoxia.
Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation.
Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice.
Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors.
Mitochondrial Redox Signaling in O<sub>2</sub>-Sensing Chemoreceptor Cells.
Author Correction: Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice.
Disruption of mitochondrial complex I induces progressive parkinsonism
Lactate sensing mechanisms in arterial chemoreceptor cells.
Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency.
Acute O<sub>2</sub> sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
Cellular adaptation to oxygen deficiency beyond the Nobel award.
Publisher Correction: Cellular adaptation to oxygen deficiency beyond the Nobel award.
The role of Olfr78 in the breathing circuit of mice
HIF-2α is essential for carotid body development and function
Glial-derived neurotrophic factor is essential for blood-nerve barrier functional recovery in an experimental murine model of traumatic peripheral neuropathy
Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's disease