Area of research
Molecular Biology · Cancer Research
Research interest
Research focused on Homologous recombination and Helicase, with related work in RAD51, DNA polymerase, Replication protein A. Notable publications include 'Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration', 'Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death', and 'DNA Sequence Alignment by Microhomology Sampling during Homologous Recombination'.
Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation
Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors
Homologous recombination–deficient mutation cluster in tumor suppressor <i>RAD51C</i> identified by comprehensive analysis of cancer variants
INTS11 regulates hematopoiesis by promoting PRC2 function
Chromatin‐bound <scp>cGAS</scp> is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers
Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection
Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates
DNA Sequence Alignment by Microhomology Sampling during Homologous Recombination
Base triplet stepping by the Rad51/RecA family of recombinases
Concentration-Dependent Exchange of Replication Protein A on Single-Stranded DNA Revealed by Single-Molecule Imaging
Protein dynamics during presynaptic-complex assembly on individual single-stranded DNA molecules
Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms
Restriction of Replication Fork Regression Activities by a Conserved SMC Complex
Down-Regulation of Rad51 Activity during Meiosis in Yeast Prevents Competition with Dmc1 for Repair of Double-Strand Breaks
Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress
A Variant of the Breast Cancer Type 2 Susceptibility Protein (BRC) Repeat Is Essential for the RECQL5 Helicase to Interact with RAD51 Recombinase for Genome Stabilization