Area of research
Molecular Biology · Physiology
Research interest
Research interests include Metabolism, Diabetes, and Cancer, Adipose Tissue and Metabolism, Pancreatic function and diabetes, and Adipokines, Inflammation, and Metabolic Diseases.
Metabolic Messengers: small extracellular vesicles
Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks
Adipose Tissue Macrophages in Metabolic Dysfunction–Associated Steatohepatitis Secrete Extracellular Vesicles That Activate Liver Fibrosis in Obese Male Mice
Lipid-associated macrophages’ promotion of fibrosis resolution during MASH regression requires TREM2
Exosome-Mediated Impact on Systemic Metabolism
IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis
Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis
Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins
Inflammation in obesity, diabetes, and related disorders
Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth
MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH
Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement
Exosomes as mediators of intercellular crosstalk in metabolism
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice
Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075
Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity
The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities
TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance
An Integrated View of Immunometabolism
Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity
Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity
Inflammatory mechanisms linking obesity and metabolic disease
Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity
Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance
G protein-coupled receptors as targets for anti-diabetic therapeutics
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
Regulation of metabolism by the innate immune system
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
GPR43 Potentiates β-Cell Function in Obesity