Area of research
Immunology · Oncology
Research interest
Research topics from publications: T cells in health and disease. Representative work: Abstract T cells are crucial for immune functions to maintain health and prevent disease. T cell development occurs in a stepwise process in the thymus and mainly generates CD4 + and CD8 + T cell subsets. Upon antigen stimulation, naïve T cells differentiate into CD4 + helper and CD8 + cytotoxic effector and memory cells, mediating direct killing, diverse immune regulatory function, and long-term protection. In response to acute and chronic infections and tumors, T cells adopt distinct differentiation trajectories and develop into a range of heterogeneous populations with various phenotype, differentiation potential, and functionality under precise and elaborate regulations of transcriptiona