Area of research
Hepatology · Epidemiology
Research interest
Research interests include Hepatocellular Carcinoma Treatment and Prognosis, Autophagy in Disease and Therapy, Cancer-related molecular mechanisms research, and RNA modifications and cancer.
Targeting non-apoptotic regulated cell death (RCD) to treat neurodegenerative diseases
Targeting mitochondria in triple-negative breast cancer: Emerging therapeutic and drug development strategies.
Targeting ATR in Cancer therapy: A drug discovery perspective.
Structure-based discovery of a novel allosteric activator of ATG4B for the treatment of triple-negative breast cancer.
Safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcinoma beyond up-to-seven criteria
Targeting spleen tyrosine kinase (SYK): structure, mechanisms and drug discovery.
Unraveling the roles of mitochondrial sirtuins in aging-related diseases: From mechanistic insights to therapeutic strategies.
Discovery of a novel Fam20C inhibitor for treatment of triple-negative breast cancer.
Repurposing antitumor drugs for the treatment of non-oncological diseases: Mechanistic insights, clinical evidence, and future perspectives.
Combination therapy and dual-target inhibitors based on cyclin-dependent kinases (CDKs): Emerging strategies for cancer therapy.
Dl‐3‐n‐Butylphthalide Promotes Cortical Angiogenesis via Akt/GSK‐3β Signaling in Ischemic Stroke Mice
Eriocalyxin B induces ferroptosis through SIRT3 inhibition in triple-negative breast cancer.
Unraveling the mysterious veil of ULK1: From non-canonical functions to therapeutic applications.
Aluminum Induced Higher Neurotoxicity than Nano-Alumina During Early Development in Zebrafish, Exacerbated by Trem2 Knockdown
Lipoic acid remodels neurovascular units through the AMPK/NLRP3 signaling pathway after cerebral infarction
Identification of immunosuppressive CD4<sup>+</sup> T-cell subtype and construction of prognostic model for hepatocellular carcinoma.
Computational identification of potential UNC-51-like kinase 1 inhibitors by an integrated structure-based and molecular dynamics-guided approach.
Corrigendum to "Discovery of a novel Fam20C inhibitor for treatment of triple-negative breast cancer" [Int. J. Biol. Macromol. 286(2024) 138398].
Immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma (CHANCE2201): a target trial emulation study
Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer.
Targeting selective autophagy and beyond: From underlying mechanisms to potential therapies.
Detection of circulating plasma cells in peripheral blood using deep learning‐based morphological analysis
Avicularin inhibits ferroptosis and improves cognitive impairments in Alzheimer's disease by modulating the NOX4/Nrf2 axis.
ATF family members as therapeutic targets in cancer: From mechanisms to pharmacological interventions.
The substitution sites of hydroxyl and galloyl groups determine the inhibitory activity of human pancreatic α-amylase in twelve tea polyphenol monomers
Unraveling the multifaceted role of SIRT7 and its therapeutic potential in human diseases.
Identification of activating transcription factor 6 (ATF6) as a novel prognostic biomarker and potential target in oral squamous cell carcinoma.
Late-stage modification of complex drug: Base-controlled Pd-catalyzed regioselective synthesis and bioactivity of arylated osimertinibs.
Targeting eukaryotic elongation factor 2 kinase (eEF2K) with small-molecule inhibitors for cancer therapy.
Combination treatment with ferroptosis and autophagy inducers significantly inhibit the proliferation and migration of oral squamous cell carcinoma.
CAREER: Towards Semantic-Centric Wireless Foundations for Swarm AI
CRII: SaTC: Adversarial Malware Generation: A Universal Evasion Framework Targeting Neural Network-based Malware Detectors
Collaborative Research: Statistical Inference for High Dimensional and High Frequency Data: Contiguity, Matrix Decompositions, Uncertainty Quantification
CRII: CNS: IoT-aware Federated On-Device Intelligence
CRII: CNS: IoT-aware Federated On-Device Intelligence
Collaborative Research: Statistical Inference for High Dimensional and High Frequency Data
Collaborative Research: Statistical Inference for High-Frequency Data
Collaborative Research: Better efficiency, better forecasting, better accuracy: A new light on the dependence structure in high frequency data