Area of research
Molecular Biology · Endocrinology, Diabetes and Metabolism
Research interest
Research interests include Hormonal Regulation and Hypertension, Ion Transport and Channel Regulation, Dental Education, Practice, Research, and Ion channel regulation and function.
Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes
Recessive genetic contribution to congenital heart disease in 5,424 probands
PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations
Isradipine therapy in Cacna1dIle772Met/+ mice ameliorates primary aldosteronism and neurologic abnormalities
Genetic dysregulation of an endothelial Ras signaling network in vein of Galen malformations
Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4
Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function
ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4<sup>PHAII</sup> mice
KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1)
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation
Mineralocorticoid Receptor Phosphorylation Regulates Ligand Binding and Renal Response to Volume Depletion and Hyperkalemia