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Yu Chen

Guangdong Academy of Medical Sciences ·
🔎 Find collaborators in Pulmonary and Respiratory Medicine · Molecular Biology →
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Area of research
Pulmonary and Respiratory Medicine · Molecular Biology
Research interest
Research interests include Prostate Cancer Treatment and Research, Epigenetics and DNA Methylation, Cancer Genomics and Diagnostics, and Gastrointestinal Tumor Research and Treatment.
h-index
67
citations
29,904
works
552
NIH funding
primary concept
Medicine
email

Recent publications

Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A–menin to bivalent promoters
Nature Genetics 2025cited by 15position: lastdoi
Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers
Science Advances 2025cited by 13position: middledoi
NSD2 targeting reverses plasticity and drug resistance in prostate cancer
Nature 2025cited by 7position: middledoi
Review of Chinese medicine intervention in PI3K/AKT pathway to regulate fibrosis
Medicine 2025cited by 3position: middledoi
A multi‐omics analysis reveals candidate genes for Cd tolerance in Paspalum vaginatum
BMC Plant Biology 2025cited by 1position: middledoi
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
Cell 2024cited by 61position: middledoi
ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
Cancer Discovery 2024cited by 42position: middledoi
Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-derived Xenograft (MDA PCa PDX) Series
Clinical Cancer Research 2024cited by 24position: middledoi
Minor intron splicing is critical for survival of lethal prostate cancer
Molecular Cell 2023cited by 20position: middledoi
Integrin-based prognostic model predicts survival, immunotherapy response, and drug sensitivity in gastric cancer
Biomedical Technology 2023cited by 13position: middledoi
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Science 2022cited by 349position: middledoi
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Science 2022cited by 265position: middledoi
Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation
Nature Communications 2022cited by 88position: middledoi
Delta-like ligand 3–targeted radioimmunotherapy for neuroendocrine prostate cancer
Proceedings of the National Academy of Sciences 2022cited by 56position: middledoi
An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence
Cancer Cell 2021cited by 257position: middledoi
Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors
Clinical Cancer Research 2021cited by 55position: middledoi
The relationship between microbial dynamics and dominant chemical components during Liupao tea processing
Food Bioscience 2021cited by 53position: middledoi
CD38 in Advanced Prostate Cancers
European Urology 2021cited by 39position: middledoi
Potentiality of α-fetoprotein (AFP) and soluble intercellular adhesion molecule-1 (sICAM-1) in prognosis prediction and immunotherapy response for patients with hepatocellular carcinoma
Bioengineered 2021cited by 35position: middledoi
Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers
Nature Communications 2021cited by 30position: middledoi
Screening and Identification of Four Prognostic Genes Related to Immune Infiltration and G-Protein Coupled Receptors Pathway in Lung Adenocarcinoma
Frontiers in Oncology 2021cited by 9position: middledoi
Two naturally occurring mutations of human GPR103 define distinct G protein selection bias
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2021cited by 4position: middledoi
Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips
Nature Genetics 2020cited by 147position: middledoi
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
Nature Communications 2020cited by 146position: middledoi
Dickkopf-1 Can Lead to Immune Evasion in Metastatic Castration-Resistant Prostate Cancer
JCO Precision Oncology 2020cited by 62position: middledoi
Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG
Proceedings of the National Academy of Sciences 2020cited by 52position: middledoi
CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis
Cancer Cell 2019cited by 124position: middledoi
The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer
EMBO Molecular Medicine 2019cited by 89position: middledoi
PARP Inhibition Suppresses GR–MYCN–CDK5–RB1–E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer
Clinical Cancer Research 2019cited by 77position: middledoi
Human liver stem cells attenuate concanavalin A-induced acute liver injury by modulating myeloid-derived suppressor cells and CD4+ T cells in mice
Stem Cell Research & Therapy 2019cited by 23position: middledoi

Grants

Data-enabled Pathways to Equity in Cyberinfrastructure Utilization for Scientific Discovery
NSF2346631$283,1632024–2027PIRePORTER
DASS: A Multi-level Collaborative Design Framework for Cross-sovereignty Software Accountability
NSF2317086$749,2322023–2026PIRePORTER
Uncovering the Mystery of the Universe's Expansion Rate with Gravitational-Wave Observations
NSF2308752$180,0002023–2027PIRePORTER
EAGER: SaTC: CORE: Small: Decentralized Data Assurance by Fair Proof of Work Consensus Federated Ledgers
NSF2141468$100,0002021–2023PIRePORTER
EAGER: SaTC: SAVED: Secure Audio and Video Data from Deepfake Attacks Leveraging Environmental Fingerprints
NSF2039342$257,0492020–2023PIRePORTER
Standardized Testing of Adult NIRS Oximetry Sensors using a Modular Phantom and Closed-loop Controlled Saturation System
NSF1935845$138,1462020–2020PIRePORTER
Standardized Testing of Adult NIRS Oximetry Sensors using a Modular Phantom and Closed-loop Controlled Saturation System
NSF2019254$138,1462020–2021PIRePORTER
Standardized Performance Testing of Multispectral Reflectance Oximetry Imaging (MROI) in Emerging Device Platforms
NSF1743660$84,2282018–2019PIRePORTER
NSF/FDA Scholar In Residence: Quantitative Characterization of Near-infrared Fluorescence Molecular Imaging Systems: 3D-printed Biomimetic Phantoms and In vivo Validation
NSF1641077$86,8682017–2018PIRePORTER
NSF/FDA SIR: 3D-printed Biomimetic Phantoms for Near-Infrared Spectroscopy System Performance Testing
NSF1542063$85,8022016–2017PIRePORTER
NSF/FDA SIR: Quantitative Characterization of Innovative Near-infrared Fluorescence Imaging Systems
NSF1445701$87,9722015–2016PIRePORTER
NSF/FDA SIR: Performance Assessment of Near-Infrared Spectroscopy Devices for Cerebral Oximetry: Dynamic Test Methods and Light-Tissue Interactions
NSF1343641$94,2862014–2015PIRePORTER
CAREER: Multi-scale Imaging of Neural Interconnects using MRI-compatible Parallel Photonic Needle Interface
NSF1254743$480,0002013–2019PIRePORTER
NSF/FDA SIR: Quantitative Characterization of Hyperspectral Reflectance Imaging Performance for Tissue Diagnostics
NSF1238407$87,5272012–2014PIRePORTER
NSF/FDA SIR: Techniques for Assessing the Performance of Optical Coherence Tomography Systems for Nanoparticle-based Detection of Gastrointestinal Cancers
NSF1135514$87,5272012–2013PIRePORTER

Frequent collaborators

Charles L. Sawyers · Molecular Oncology (United States)9 papers (2013–2025)Dong Gao · University of Electronic Science and Technology of China9 papers (2013–2020)Ping Chi · Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University7 papers (2013–2018)John Wongvipat · Memorial Sloan Kettering Cancer Center7 papers (2013–2018)Andrea Sboner · Cornell University6 papers (2014–2019)Leili Ran · Tsinghua University5 papers (2014–2018)Mark A. Rubin · Praxis5 papers (2016–2023)Brett S. Carver · New York Hospital Queens5 papers (2013–2025)Deyou Zheng · Albert Einstein College of Medicine5 papers (2013–2017) · 4 papers (2013–2018)Zhen Cao · Wageningen University & Research4 papers (2014–2018) · 4 papers (2016–2018) · 4 papers (2016–2018)Himisha Beltran · Harvard University4 papers (2016–2019)Elissa W.P. Wong · Rockefeller University4 papers (2017–2019)Youxin Guan · University of Louisville4 papers (2016–2018)Dan Li · Southern University of Science and Technology4 papers (2017–2025)Devan Murphy · University of California, Davis3 papers (2017–2018)Shangqian Wang · Nanjing Medical University3 papers (2017–2018)Yunqian Pan · Indiana University School of Medicine3 papers (2018–2019)
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