Area of research
Pharmacology · Oncology
Research interest
Research interests include Drug Transport and Resistance Mechanisms, Pharmacogenetics and Drug Metabolism, Pharmacological Effects of Natural Compounds, and Plant-based Medicinal Research.
Development and application of a CNS PBPK model that integrates CSF dynamics to optimize dosing regimens of antibacterial agents in pediatric patients with meningitis
Virtual Bioequivalence Assessment and Dissolution Safe Space Exploration for Fixed-Dose Metformin-Glyburide Tablet Using Physiologically Based Biopharmaceutics Modeling.
A physiologically-based quantitative systems pharmacology model for mechanistic understanding of the response to alogliptin and its application in patients with renal impairment.
A real-world pharmacovigilance study of QT interval prolongation and Torsades de Pointes associated with CDK4/6 inhibitors in breast cancer patients: findings from the FDA adverse event reporting system.
Investigation into the impact of proton pump inhibitors on sertraline transport across the blood-brain barrier
Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms.
A sensitive, heart-cutting, two-dimensional liquid chromatography–tandem mass spectrometry method for the determination of mometasone furoate in human plasma: Application for a bioequivalence study in nasal spray formulations
Enhancing Paclitaxel Efficacy with Piperine-Paclitaxel Albumin Nanoparticles in Multidrug-Resistant Triple-Negative Breast Cancer by Inhibiting P-Glycoprotein.
Genome-Wide Association Analysis of Protein-Coding Variants in IgA Nephropathy
Physiologically Based Pharmacokinetic Modeling to Simulate CYP3A4-Mediated Drug-Drug Interactions for Pyrotinib.
Evaluation of Safety of Treatment With Anti–Epidermal Growth Factor Receptor Antibody Drug Conjugate MRG003 in Patients With Advanced Solid Tumors
Changes in target ability of nanoparticles due to protein corona composition and disease state.
Targeted inhibition of FcRn reduces NET formation to ameliorate experimental ulcerative colitis by accelerating ANCA clearance.
Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme.
Physiologically based pharmacokinetic modeling of brivaracetam and its interactions with rifampin based on CYP2C19 phenotypes.
The Addition of Ferritin Enhanced the Prognostic Value of International Prognostic Index in Diffuse Large B‐Cell Lymphoma
Tanshinone IIA prevents acetaminophen-induced nephrotoxicity through the activation of the Nrf2-Mrp2/4 pathway in mice.
Tanshinone IIA alleviate rifampicin-induced cholestasis by regulating the expression and function of bile salt export pump.
Physiologically based pharmacokinetic modeling of tramadol to inform dose adjustment and drug-drug interactions according to CYP2D6 phenotypes.
Physiologically Based Pharmacokinetic Modeling in Pregnant Women Suggests Minor Decrease in Maternal Exposure to Olanzapine.
Dose Adjustment of Quetiapine and Aripiprazole for Pregnant Women Using Physiologically Based Pharmacokinetic Modeling and Simulation.
Pipette-tip micro-solid phase extraction based on melamine-foam@polydopamine followed by ultra-high-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry for detection of psychotropic drugs in human serum.
Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL-35.
Quantitation of Apremilast in Beagle Dogs Plasma by UPLC-MS-MS and Its Application to Pharmacokinetic Studies.
A rapid and sensitive High-Performance Liquid Chromatography-tandem Mass Spectrometry method for determining apremilast in beagle dog plasma and urine: Application in a pharmacokinetic study
Enhanced Cancer-targeted Drug Delivery Using Precoated Nanoparticles.
The diverse functions of Siglec-15 in bone remodeling and antitumor responses
Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2.
Tanshinone IIA attenuates acetaminophen-induced hepatotoxicity through HOTAIR-Nrf2-MRP2/4 signaling pathway.
Metabolite identification, tissue distribution, excretion and preclinical pharmacokinetic studies of ET-26-HCl, a new analogue of etomidate.
Deep Learning for Survival Analysis, Causal Inference, and Conformal Inference,
Testing and Deep Learning for Functional Data
Modeling and Radiosonde Data Investigations of Turbulence and Mixing in the Vicinity of the Tropopause
Collaborative Research: Processes Determining the Climatology of Atmospheric Unstable Layers
Complex Problems in Functional Data Analysis
Collaborative Research: Modeling the Nonlinear Dynamics of Deep Gravity Waves in the Mesosphere and Thermosphere
Atmospheric Turbulence - Detailed Modeling and Characterization from Radosonde Observations
Functional Data Analysis: From Univariate to High-Dimensional Functional Data
New Directions in Functional Data Analysis
Wave Characteristics from the COSMIC and CHAMP Global Positioning System (GPS) Temperature Profiles
Functional Analysis of Sparse Longitudinal Data
Statistical Modelling and Dimension Reduction for Functional Data
Mathematical Sciences: Innovative Statistical Methods for Biological Life Spans and Oldest-Old Mortality
Mathematical Sciences: Some Problems for Incomplete Survival Data