Area of research
Molecular Biology · Materials Chemistry
Research interest
Research focused on RNA and RNA-binding protein, with related work in RNA splicing, SR protein, Tryptophan. Notable publications include 'Application of tyrosine-tryptophan fluorescence resonance energy transfer in monitoring protein size changes', 'Native State Volume Fluctuations in Proteins as a Mechanism for Dynamic Allostery', and 'Intrinsically disordered electronegative clusters improve stability and binding specificity of RNA-binding proteins'.
Controlled by disorder: Phosphorylation modulates <scp>SRSF1</scp> domain availability for spliceosome assembly
Unearthing a novel function of SRSF1 in binding and unfolding of RNA G-quadruplexes
The <scp>U1</scp>‐<scp>70K</scp> and <scp>SRSF1</scp> interaction is modulated by phosphorylation during the early stages of spliceosome assembly
Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions
Intra- and inter-molecular regulation by intrinsically-disordered regions governs PUF protein RNA binding
N-terminal domain of tyrosyl-DNA phosphodiesterase I regulates topoisomerase I-induced toxicity in cells
Poly(<i>N</i>-vinylpyrrolidone)-<i>block</i>-Poly(dimethylsiloxane)-<i>block</i>-Poly(<i>N</i>-vinylpyrrolidone) Triblock Copolymer Polymersomes for Delivery of PARP1 siRNA to Breast Cancers
Inter-domain Flexibility of Human Ser/Arg-Rich Splicing Factor 1 Allows Variable Spacer Length in Cognate RNA’s Bipartite Motifs
Intrinsically disordered electronegative clusters improve stability and binding specificity of RNA-binding proteins
Application of tyrosine-tryptophan fluorescence resonance energy transfer in monitoring protein size changes
Native State Volume Fluctuations in Proteins as a Mechanism for Dynamic Allostery
Alpha-1-antitrypsin interacts with gp41 to block HIV-1 entry into CD4+ T lymphocytes