Area of research
Public Health, Environmental and Occupational Health · Reproductive Medicine
Research interest
Research interests include Reproductive Biology and Fertility, Sperm and Testicular Function, Ovarian function and disorders, and Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities.
CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs.
Human oocyte quality and reproductive health
Genetic landscape of human oocyte/embryo defects
Liposomal glytrexate formulation: improving antitumour efficacy and minimizing toxicity in breast cancer therapy
Pathogenic variants in DLGAP5 cause female infertility characterized by oocyte maturation arrest and embryonic arrest.
The E3 ubiquitin ligase adaptor KLHL8 targets ZAR1 to regulate maternal mRNA degradation in oocytes.
Mechanisms of minor pole–mediated spindle bipolarization in human oocytes
<i>COX15</i> deficiency causes oocyte ferroptosis
Mechanisms of minor pole-mediated spindle bipolarization in human oocytes.
<i>COX15</i> deficiency causes oocyte ferroptosis.
Identification novel mutations and phenotypic spectrum expanding in PATL2 in infertile women with IVF/ICSI failure
CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice
Genetic factors of oocyte maturation arrest: an important cause for recurrent IVF/ICSI failures
Genetic factors of oocyte maturation arrest: an important cause for recurrent IVF/ICSI failures.
Understanding the genetics of human infertility
Understanding the genetics of human infertility.
Large-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects
Sodium alginate hydrogel integrated with type III collagen and mesenchymal stem cell to promote endometrium regeneration and fertility restoration
PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1
AMPK phosphorylates and stabilises copper transporter 1 to synergise metformin and copper chelator for breast cancer therapy
Bi‐allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility
PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1.
Karyopherin α deficiency contributes to human preimplantation embryo arrest.
Bi-allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility.
Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes.
YBX2-dependent stabilization of oocyte mRNA through a reversible sponge-like cortical partition.
A novel homozygous variant in ZFP36L2 cause female infertility due to oocyte maturation defect.
IQUB deficiency causes male infertility by affecting the activity of p-ERK1/2/RSPH3.
Genetic screening in patients with ovarian dysfunction.
ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1.