Area of research
Molecular Biology · Materials Chemistry
Research interest
Research interests include Ubiquitin and proteasome pathways, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, and Autophagy in Disease and Therapy.
Sadoamides A and B: Bacterial Tripeptides Incorporating Nonproteinogenic Amino Acids as Proteasome Inhibitors.
PINK1 and STUB1 pathway orchestrates peroxisomal selective autophagy by PEX13 depletion.
Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy.
Tumor-promoting UBR4 coordinates impaired mitophagy–associated senescence and lung adenocarcinoma pathogenesis
Extracellular Vesicle-Mediated Delivery of 20S Proteasomes Enhances Tau Degradation in Recipient Cells.
Tumor-promoting UBR4 coordinates impaired mitophagy-associated senescence and lung adenocarcinoma pathogenesis.
Pathogenic roles of immunoproteasomes in fibrosis.
USP15: the fourth Proteasome-associated DUB
Targeted protein degradation directly engaging lysosomes or proteasomes
Targeted protein degradation directly engaging lysosomes or proteasomes.
Self-assembly of tau fragments as a key pathologic event in tauopathies.
The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10.
Self-Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice.
Sadopeptins A and B, Sulfoxide- and Piperidone-Containing Cyclic Heptapeptides with Proteasome Inhibitory Activity from a <i>Streptomyces</i> sp.
Self-aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice
Self-aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice
Effects of mTORC1 inhibition on proteasome activity and levels
Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates.
ECPAS/Ecm29-Mediated 26S Proteasome Disassembly is an Adaptive Response to Glucose Starvation
CHIP-mediated hyperubiquitylation of tau promotes its self-assembly into the insoluble tau filaments.
Concept and application of circulating proteasomes.
Formation of Non-Nucleoplasmic Proteasome Foci during the Late Stage of Hyperosmotic Stress.
The Antipsychotic Drug Clozapine Suppresses the RGS4 Polyubiquitylation and Proteasomal Degradation Mediated by the Arg/N-Degron Pathway.
Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes.
Docosahexaenoic Acid, a Potential Treatment for Sarcopenia, Modulates the Ubiquitin-Proteasome and the Autophagy-Lysosome Systems.
Pentaminomycins C-E: Cyclic Pentapeptides as Autophagy Inducers from a Mealworm Beetle Gut Bacterium.
ATP Kinetically Modulates Pathogenic Tau Fibrillations.
Proteasome Activity in the Plasma as a Novel Biomarker in Mild Cognitive Impairment with Chronic Tinnitus.
Reduced chronic restraint stress in mice overexpressing hyperactive proteasomes in the forebrain.
Negative-feedback coordination between proteasomal activity and autophagic flux.
Collaborative Research: DASS: Enabling Standards- and Disclosure-Based Regulations in and through Software Systems: Making Algorithmic Work Management Software Accountable to Law
Collaborative Research: Effect of Cyclic Mechanical Stress on Ionic Conduction in Composite Polymer Electrolytes for Solid-State Batteries
CAREER: Probing Oxygen-Mediated Electrochemical Processes of Oxides at High Spatial and Temporal Resolution
I-Corps: Neuromorphic device derived from resistive switching system
RUI: Multidimensional Conservation Laws
Collaborative Research: SOCIUS: Socially Responsible Smart Cities
HF Heater Effect on Natural Spread F Phenomenon at Arecibo, Puerto Rico
Ion Acoustic Wave Turbulence in Ionospheric Plasmas